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Co-administration of Anti microRNA-124 and -137 Oligonucleotides Prevents Hippocampal Neural Stem Cell Loss Upon Non-convulsive Seizures

Bielefeld, Pascal; Schouten, Marijn; Meijer, Guido M.; Breuk, Marit J.; Geijtenbeek, Karlijne; Karayel, Sedef; Tiaglik, Alisa; Vuuregge, Anna H.; Willems, Ruth A.L.; Witkamp, Diede; Lucassen, Paul J.; Encinas Pérez, Juan Manuel; Fitzsimons, Carlos P. (Frontiers Media, 2019-02-19)

Convulsive seizures promote adult hippocampal neurogenesis (AHN) through a transient activation of neural stem/progenitor cells (NSPCs) in the subgranular zone (SGZ) of the dentate gyrus (DG). However, in a significant ...

Reactive Disruption of the Hippocampal Neurogenic Niche After Induction of Seizures by Injection of Kainic Acid in the Amygdala

Muro García, Teresa; Martín Suárez, Soraya; Espinosa, Nelson; Valcárcel Martín, Roberto; Marinas, Ainhoa; Zaldumbide Dueñas, Laura; Galbarriatu, Lara; Sierra Saavedra, Amanda; Fuentealba, Pablo; Encinas Pérez, Juan Manuel (Frontiers Media, 2019-08-20)

Adult neurogenesis persists in the adult hippocampus due to the presence of multipotent neural stem cells (NSCs). Hippocampal neurogenesis is involved in a range of cognitive functions and is tightly regulated by neuronal ...

Perspective: Of Mice and Men - How Widespread Is Adult Neurogenesis?

Petrik, David; Encinas Pérez, Juan Manuel (Frontiers Media, 2019-08-29)

These are exciting times for research on adult hippocampal neurogenesis (AHN). Debate and controversy regarding the existence of generation of new neurons in the adult, and even diseased human brain flourishes as articles ...

Phenotypical and functional heterogeneity of neural stem cells in the aged hippocampus

Martín Suárez, Soraya; Valero Gómez-Lobo, Jorge; Muro García, Teresa; Encinas Pérez, Juan Manuel (Wiley, 2019-08)

Adult neurogenesis persists in the hippocampus of most mammal species during postnatal and adult life, including humans, although it declines markedly with age. The mechanisms driving the age-dependent decline of hippocampal ...

Circadian glucocorticoid oscillations preserve a population of adult hippocampal neural stem cells in the aging brain

Schouten, Marijn; Bielefeld, Pascal; García Corzo, L.; Passchier, E. M. J.; Gradari, S.; Jungenitz, T.; Pons Espinal, M.; Gebara, E.; Martín Suárez, Soraya; Lucassen, Paul J.; De Vries, H. E.; Trejo Pérez, Jose Luis; Schwarzacher, S. W.; De Pietri Tonelli, D.; Toni, N.; Mira, H.; Encinas Pérez, Juan Manuel; Fitzsimons, Carlos P. (Springer, 2019-06-20)

A decrease in adult hippocampal neurogenesis has been linked to age-related cognitive impairment. However, the mechanisms involved in this age-related reduction remain elusive. Glucocorticoid hormones (GC) are important ...