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Evaluación de la capacidad antioxidante tras el debut de un trastorno mental grave.
(2019-05-08)
Existe gran evidencia de que el estrés oxidativo juega un papel fundamental en el desarrollo del trastorno mental grave. El objetivo de esta tesis doctoral es estudiar los niveles de capacidad antioxidante tras el debut ...
Mediating role of cognition and social cognition on creativity among patients with schizophrenia and healthy controls: Revisiting the Shared Vulnerability Model
(Wiley, 2019-12)
Aim As suggested by the Shared Vulnerability Model, impairment in executive functions could lead to worse creative performance among individuals with schizophrenia. Another impaired function in schizophrenia, previously ...
Impacto de la estimulación subtalámica a largo plazo sobre la situación cognitiva de los pacientes con enfermedad de Parkinson avanzada
(Elsevier, 2019-06-13)
Objetivo
El objetivo es evaluar los efectos de la estimulación cerebral profunda del núcleo subtalámico bilateral (STN-DBS) sobre el estado cognitivo de los pacientes con enfermedad de Parkinson 5 años después de la ...
The MAPT H1 Haplotype Is a Risk Factor for Alzheimer’s Disease in APOE ε4 Non-carriers
(Frontiers Media, 2019-12-04)
An ancestral inversion of 900 kb on chromosome 17q21, which includes the microtubule-associated protein tau (MAPT) gene, defines two haplotype clades in Caucasians (H1 and H2). The H1 haplotype has been linked inconsistently ...
Leukocyte telomere length in patients with myotonic dystrophy type I: a pilot study
(Wiley, 2019-12)
Myotonic dystrophy type I (DM1) is an autosomal dominant disease of which clinical manifestations resemble premature aging. We evaluated the contribution of telomere length in pathogenesis in 361 DM1 patients (12 with ...
AHK konposatuen efikazia duchenne muskulu-distrofiaren animalia-ereduetan
(2019-12-18)
Duchenne muskulu-distrofia (DMD) gaixotasun neuromuskular larria da eta X kromosoman dagoen distrofinaren geneko mutazio azpirakorrak dira erantzuleak. 3500 mutiletik bati eragiten dio batez beste eta, gaur egun, sendabiderik ...
Microglial phagocytosis: unraveling the role of GPR34-LYSOPS signaling and phagocytic microglia on metabolism and neurogenesis
(2019-06-20)
Las células de microglía constituyen los fagocitos residentes del cerebro. Una de las principales funciones de las células de microglía consiste en la fagocitosis de células apoptóticas. La fagocitosis depende de diversos ...
Co-administration of Anti microRNA-124 and -137 Oligonucleotides Prevents Hippocampal Neural Stem Cell Loss Upon Non-convulsive Seizures
(Frontiers Media, 2019-02-19)
Convulsive seizures promote adult hippocampal neurogenesis (AHN) through a transient activation of neural stem/progenitor cells (NSPCs) in the subgranular zone (SGZ) of the dentate gyrus (DG). However, in a significant ...
Parkinson disease-associated mutations in LRRK2 cause centrosomal defects via Rab8a phosphorylation
(Biomed Central, 2019-01-23)
Background: Mutations in LRRK2 are a common genetic cause of Parkinson's disease (PD). LRRK2 interacts with and phosphorylates a subset of Rab proteins including Rab8a, a protein which has been implicated in various ...
APP depletion alters selective pre- and post-synaptic proteins
(Elsevier, 2019-03)
The normal role of Alzheimer's disease (AD)-linked amyloid precursor protein (APP) in the brain remains incompletely understood. Previous studies have reported that lack of APP has detrimental effects on spines and ...