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Gut microbiome and serum metabolome analyses identify molecular biomarkers and altered glutamate metabolism in fibromyalgia
(Elsevier, 2019-08)
Background: Fibromyalgia is a complex, relatively unknown disease characterised by chronic, widespread musculoskeletal pain. The gut-brain axis connects the gut microbiome with the brain through the enteric nervous system ...
Evidence of conditioned behavior in amoebae
(Nature, 2019-08-15)
Associative memory is the main type of learning by which complex organisms endowed with evolved nervous systems respond efficiently to certain environmental stimuli. It has been found in different multicellular species, ...
Mortality Risks after Two Years in Frail and Pre-Frail Older Adults Admitted to Hospital
(MDPI, 2023-04-24)
Background: Frailty is characterized by a progressive decline in the physiological functions of multiple body systems that lead to a more vulnerable condition, which is prone to the development of various adverse events, ...
Effects of the absence of TRPV1 in the expression of the cannabinoid 1 (CB1) receptor in the brain
(2023-04-05)
[EN] Though cannabinoids functions in the brain are typically associated with the activation of cannabinoid receptor 1 (CB1R), several effects depend on the activation of TRPV1, a receptor from the transient receptor ...
Mapping of plasticity and stress-related markers in acute and chronic stress in rats
(2023-04-05)
[EN] Stress is a physiological response to any kind of demand or threat that challenges the homeostasis of the organism. Although stress increases alertness and performance, excessive stress often negatively affects cognitive ...
Analysis of Plasminogen Genetic Variants in Multiple Sclerosis Patients
(Genetics Society of America, 2016-07-01)
Multiple sclerosis (MS) is a prevalent neurological disease of complex etiology. Here, we describe the characterization of a multi-incident MS family that nominated a rare missense variant (p.G420D) in plasminogen (PLG) ...