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Resveratrol Metabolites Modify Adipokine Expression and Secretion in 3T3-L1 Pre-Adipocytes and Mature Adipocytes
(Public Library of Science, 2013-05)
Objective: Due to the low bioavailability of resveratrol, determining whether its metabolites exert any beneficial effect is an interesting issue.
Methods: 3T3-L1 maturing pre-adipocytes were treated during differentiation ...
Association between dietary phylloquinone intake and peripheral metabolic risk markers related to insulin resistance and diabetes in elderly subjects at high cardiovascular risk
(BioMed Central, 2013-01)
Background: Vitamin K has been related to glucose metabolism, insulin sensitivity and diabetes. Because inflammation underlies all these metabolic conditions, it is plausible that the potential role of vitamin K in glucose ...
High-Throughput Sequencing of microRNAs in Peripheral Blood Mononuclear Cells: Identification of Potential Weight Loss Biomarkers
(Public Library of Science (PLoS), 2013)
INTRODUCTION: MicroRNAs (miRNAs) are being increasingly studied in relation to energy metabolism and body composition homeostasis. Indeed, the quantitative analysis of miRNAs expression in different adiposity conditions ...
Mechanism of transport of saquinavir-loaded nanostructured lipid carriers across the intestinal barrier
(Elsevier, 2013)
[EN] The aims of this work were (i) to evaluate the potential of nanostructured lipid carriers (NLCs) as a tool to 24
enhance the oral bioavailability of poorly soluble compounds using saquinavir (SQV), a BCS class IV ...
Intranasal Delivery of Plasma and Platelet Growth Factors Using PRGF-Endoret System Enhances Neurogenesis in a Mouse Model of Alzheimer’s Disease
(PLoS ONE, 2013-09-19)
[EN] Neurodegeneration together with a reduction in neurogenesis are cardinal features of Alzheimer’s disease (AD) induced by a combination of toxic amyloid-β peptide (Aβ) and a loss of trophic factor support. Amelioration ...
Biosimilar medicines in dermatology: key aspects
(Bryn Mawr Communications III LLC, 2013-02)
En el artículo se recoge la aplicación de los medicamentos biosimilares biotecnológicos) en patologías dermatológicas.
Association analyses of DNA polymorphisms in bovine SREBP-1, LXRα,FADS1 genes with fatty acid composition in Canadian commercial crossbred beef steers
(Elsevier, 2013-03)
Two previously reported DNA polymorphisms of sterol regulatory element binding transcription factor 1 (SREBP1) and liver X receptor alpha (LXRα) and two DNA
polymorphisms of fatty acid desaturase 1 (FADS1) were evaluated ...
rhegf-Loaded Plga-Alginate Microspheres Enhance The Healing Of Full-Thickness Excisional Wounds In Diabetised Wistar Rats
(Elsevier, 2013)
[EN] Diabetic foot ulcers (DFUs) represent a major clinical challenge in the ageing
population. To address this problem, rhEGF-loaded Poly-Lactic-co-Glycolic-Acid (PLGA)-Alginate microspheres (MS) were prepared by a ...
Desarrollo de nanopartículas sólidas lipídicas como sistemas de administración de ADN para terapia génica
(2013-10-24)
[EN] This work includes the development, characterization and optimization of a gene delivery system based on solid lipid nanoparticles (SLNs) . Formulations were characterized in terms of particle size , surface charge ...
Nanostructured lipid carriers as vehicles for the delivery of poorly water-soluble drugs
(2013-05-28)
El objetivo de esta tesis ha sido el desarrollo de una formulación basada en NLCs para la administración de fármacos poco solubles, tanto por vía oral como por vía intravenosa. Para ello: 1. Se ha llevado a cabo la evaluación ...