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Identification of Tick Saliva Antigens as Vaccine Candidates and Immunotherapeutics
(2017-10-27)
Mice are widely used in research. This animal species has also beenextensively used to study the relationship between ticks and their mammalian hosts,including the design and test of vaccine candidates, although it is ...
Solid Lipid Nanoparticles Loaded with Glucocorticoids Protect Auditory Cells from Cisplatin-Induced Ototoxicity
(MDPI, 2019-09-14)
Cisplatin is a chemotherapeutic agent that causes the irreversible death of auditory sensory cells, leading to hearing loss. Local administration of cytoprotective drugs is a potentially better option co-therapy for ...
Integration Through Separation - The Role of Lateral Membrane Segregation in Nutrient Uptake
(Frontiers Media, 2019-06-25)
Nutrient transporters are prominent and ubiquitous components of the plasma membrane in all cell types. Their expression and regulation are tightly linked to the cells' needs. Environmental factors such as nutrient starvation ...
Bases estructurales del transporte de Mg2+ mediado por los factores homeostáticos CNNM2 y CNNM4, y de su interacción oncogénica con las fosfatasas PRL.
El Magnesio, segundo catión intracelular más abundante, es un ión imprescindible en diversas funciones vitales como la neurotransmisión, la conductancia cardiaca o la síntesis de ATP. Este papel biológico trascendental ...
Dermal Delivery of the High-Molecular-Weight Drug Tacrolimus by Means of Polyglycerol-Based Nanogels
(MDPI, 2019-08)
Polyglycerol-based thermoresponsive nanogels (tNGs) have been shown to have excellent skin hydration properties and to be valuable delivery systems for sustained release of drugs into skin. In this study, we compared the ...
Characterization of USP11 as a novel regulator of Hypoxia inducible factor a
(2019-11-27)
Adaptation to hypoxia is a puzzling and tightly regulated challenge. This adaptability involves a severe gene expression rewiring, which is mainly triggered by the Hypoxia Inducible transcription Factor (HIF). Canonically, ...
Molecular recognition between PCNA and proteins involved in DNA replication and repair: p15 and p12
(2019-12-19)
El antígeno nuclear de células en proliferación (PCNA) es un factor esencial en replicación y reparación de ADN en eucariotas. Forma un anillo homotrimérico que rodea y se desliza a lo largo del ADN, actuando como una ...
Targeting PML in triple negative breast cancer elicits growth suppression and senescence
(Nature, 2020-04)
Oncogene addiction postulates that the survival and growth of certain tumor cells is dependent upon the activity of one oncogene, despite their multiple genetic and epigenetic abnormalities. This phenomenon provides a ...
Multiplex SERS Detection of Metabolic Alterations in Tumor Extracellular Media
(Wiley, 2020-04)
The composition and intercellular interactions of tumor cells in the tissues dictate the biochemical and metabolic properties of the tumor microenvironment. The metabolic rewiring has a profound impact on the properties ...
Contextualization of the Bioeconomy Concept through Its Links with Related Concepts and the Challenges Facing Humanity
(MDPI, 2021-07-12)
The concept of bioeconomy is a topic of debate, confusion, skepticism, and criticism. Paradoxically, this is not necessarily a negative thing as it is encouraging a fruitful exchange of information, ideas, knowledge, and ...