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Stromal oncostatin M cytokine promotes breast cancer progression by reprogramming the tumor microenvironment
(American Society of Clinical Investigation, 2022-04-01)
[EN] The tumor microenvironment (TME) is reprogrammed by cancer cells and participates in all stages of tumor progression. The contribution of stromal cells to the reprogramming of the TME is not well understood. Here, we ...
Instauración del fundamento terapéutico de la inhibición de la vía de señalización Lefty-Smad en el Glioblastoma
(2022-04-21)
El Glioblastoma es el tumor cerebral primario más frecuente y agresivo del Sistema Nervioso Central. Presenta un pronóstico muy pobre, con una mediana de supervivencia menor a los 15 meses, y los costes en la sociedad ...
Unveiling the activation dynamics of a fold-switch bacterial glycosyltransferase by 19F NMR
(American Society for Biochemistry and Molecular Biology, 2020-07-17)
Fold-switch pathways remodel the secondary structure topology of proteins in response to the cellular environment. It is a major challenge to understand the dynamics of these folding processes. Here, we conducted an in-depth ...
Structural studies of filamentous plant viruses by cryo-electron microscopy and cryo-electron tomography
(2021-09-09)
Los virus filamentosos flexibles de plantas representan un grupo de patógenos de plantas que causan un gran impacto económico en cultivos dedicados a la agricultura. El géneropotyvirus es el más numeroso y abarca hasta un ...
Microfluidic chip with pillar arrays for controlled production and observation of lipid membrane nanotubes
(Royal Society of Chemistry, 2020-08-07)
Lipid membrane nanotubes (NTs) are a widespread template forin vitrostudies of cellular processes happening at high membrane curvature. Traditionally NTs are manufactured one by one, using sophisticated membrane ...
High SOX9 Maintains Glioma Stem Cell Activity through a Regulatory Loop Involving STAT3 and PML
(MDPI, 2022-05)
Glioma stem cells (GSCs) are critical targets for glioma therapy. SOX9 is a transcription factor with critical roles during neurodevelopment, particularly within neural stem cells. Previous studies showed that high levels ...
Phosphatidic Acid Stimulates Myoblast Proliferation through Interaction with LPA1 and LPA2 Receptors
(MDPI, 2021-02-01)
Phosphatidic acid (PA) is a bioactive phospholipid capable of regulating key biological functions, including neutrophil respiratory burst, chemotaxis, or cell growth and differentiation. However, the mechanisms whereby PA ...
Mechanism for ESCPE-1 mediated membrane remodelling and cargo selection in endosomal
(2020-10-02)
El reciclaje de proteínas es fundamental para mantener la homeostasis celular. Este trabajo se enfoca en el reciclaje de proteínas que llegan a los endosomas. Allí, las proteínas transmembrana (receptores) son recicladas ...
Erythrocyte Membrane Nanomechanical Rigidity Is Decreased in Obese Patients
(MDPI, 2022-02-08)
This work intends to describe the physical properties of red blood cell (RBC) membranes in obese adults. The hypothesis driving this research is that obesity, in addition to increasing the amount of body fat, will also ...
A fluorogenic cyclic peptide for imaging and quantification of drug-induced apoptosis
(Nature, 2020-08-12)
Programmed cell death or apoptosis is a central biological process that is dysregulated in many diseases, including inflammatory conditions and cancer. The detection and quantification of apoptotic cells in vivo is hampered ...