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Physiological and molecular basis determining inter-individual growth rate differences in spat of the mussel Mytilus galloprovincialis reared under different nutritional and temperature environments.
(2018-12-05)
En el presente trabajo se exponen los resultados obtenidos en una serie de experimentos diseñados para confirmar o rechazar la hipótesis de que las características fisiológicas que generan diferencias entre individuos de ...
Doxorubicin-induced DNA Damage Causes Extensive Ubiquitination of Ribosomal Proteins Associated with a Decrease in Protein Translation
(American Society for Biochemistry and Molecular Biology, 2018-12)
Protein posttranslational modifications (PTMs) play a central role in the DNA damage response. In particular, protein phosphorylation and ubiquitination have been shown to be essential in the signaling cascade that coordinates ...
Mir-pharmacogenetics in childhood acute lymphoblastic leukemia treatment
(2018-09-20)
La leucemia Linfoblástica Aguda (LLA) es la neoplasia más frecuente en la población pediátrica. La supervivencia global de la LLA supera hoy día el 80%, en parte gracias a la intensificación del tratamiento. Sin embargo, ...
Maternal DNA lineages at the gate of Europe in the 10th century AD
(Public Library of Science, 2018-03-14)
Given the paucity of archaeogenetic data available for medieval European populations in comparison to other historical periods, the genetic landscape of this age appears as a puzzle of dispersed, small, known pieces. In ...
Does Arterial Hypertension Influence the Onset of Huntington's Disease?
(Public Library Science, 2018-05-23)
Huntington's disease (HD) age of onset (AO) is mainly determined by the length of the CAG repeat expansion in the huntingtin gene. The remaining AO variability has been attributed to other little-known factors. A factor ...
Transcription Factor Binding Site Enrichment Analysis In Co-Expression Modules In Celiac Disease
(MDPI, 2018-05-10)
The aim of this study was to construct celiac co-expression patterns at a whole genome level and to identify transcription factors (TFs) that could drive the gliadin-related changes in coordination of gene expression ...
Association of Current and Former Smoking With Body Mass Index: a Study of Smoking Discordant Twin Pairs From 21 Twin Cohorts
(Public Library Science, 2018-07-12)
Background
Smokers tend to weigh less than never smokers, while successful quitting leads to an increase in body weight. Because smokers and non-smokers may differ in genetic and environmental family background, we ...
An E2F7-Dependent Transcriptional Program Modulates DNA Damage Repair And Genomic Stability
(Oxford University Press, 2018-05-18)
The cellular response to DNA damage is essential for maintaining the integrity of the genome. Recent evidence has identified E2F7 as a key player in DNA damage-dependent transcriptional regulation of cell-cycle genes. ...
Variants in the 14q32 miRNA cluster are associated with osteosarcoma risk in the Spanish population
(Nature Publishing, 2018-10-18)
Association studies in osteosarcoma risk found significant results in intergenic regions, suggesting that regions which do not codify for proteins could play an important role. The deregulation of microRNAs (miRNAs) has ...