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Metabolic alterations in prostate cancer pathogenesis
(2016-09-16)
Activation of the PTEN-PI3K-mTORC1 pathway consolidates metabolic programs thatsustain cell growth, proliferation and promote cancer initiation and progression. In this thesis workwe describe a novel molecular mechanism ...
Structural remodeling and oligomerization of human cathelicidin on membranes suggest fibril-like structures as active species
(Nature Publishing, 2017-11-13)
Antimicrobial peptides as part of the mammalian innate immune system target and remove major bacterial pathogens, often through irreversible damage of their cellular membranes. To explore the mechanism by which the important ...
Physical principles underlying structure, mechanics and dynamic re-organization of hyaluronan-rich matrices - from tissues to supramolecular models in experiment and theory
(2016-07-29)
The goal of this research project is to understand the physical principles that underlie the structure, mechanics and dynamic reorganization of hyaluronan-rich pericellular and extracellular matrices. Many cells produce a ...
Structural basis of glycogen biosynthesis regulation in bacteria
(2017-09-26)
ADP-glucosa pirofosforilasa (AGPasa) es la enzyma responsable de la formación de ADP-glucosa, reacción limitante en la biosíntesis de glucógeno en bacterias y almidón en plantas, y su actividad se encuentra regulada ...
What to consider when pseudohypoparathyroidism is ruled out: iPPSD and differential diagnosis
(Biomed Central, 2018-03-02)
Background: Pseudohypoparathyroidism (PHP) is a rare disease whose phenotypic features are rather difficult to identify in some cases. Thus, although these patients may present with the Albright's hereditary osteodystrophy ...
Identification of Tick Saliva Antigens as Vaccine Candidates and Immunotherapeutics
(2017-10-27)
Mice are widely used in research. This animal species has also beenextensively used to study the relationship between ticks and their mammalian hosts,including the design and test of vaccine candidates, although it is ...
Solid Lipid Nanoparticles Loaded with Glucocorticoids Protect Auditory Cells from Cisplatin-Induced Ototoxicity
(MDPI, 2019-09-14)
Cisplatin is a chemotherapeutic agent that causes the irreversible death of auditory sensory cells, leading to hearing loss. Local administration of cytoprotective drugs is a potentially better option co-therapy for ...
Integration Through Separation - The Role of Lateral Membrane Segregation in Nutrient Uptake
(Frontiers Media, 2019-06-25)
Nutrient transporters are prominent and ubiquitous components of the plasma membrane in all cell types. Their expression and regulation are tightly linked to the cells' needs. Environmental factors such as nutrient starvation ...
Dermal Delivery of the High-Molecular-Weight Drug Tacrolimus by Means of Polyglycerol-Based Nanogels
(MDPI, 2019-08)
Polyglycerol-based thermoresponsive nanogels (tNGs) have been shown to have excellent skin hydration properties and to be valuable delivery systems for sustained release of drugs into skin. In this study, we compared the ...
Characterization of USP11 as a novel regulator of Hypoxia inducible factor a
(2019-11-27)
Adaptation to hypoxia is a puzzling and tightly regulated challenge. This adaptability involves a severe gene expression rewiring, which is mainly triggered by the Hypoxia Inducible transcription Factor (HIF). Canonically, ...