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GSE4-Loaded Nanoparticles a Potential Therapy for Lung Fibrosis that Enhances Pneumocyte Growth, Reduces Apoptosis and DNA Damage
(Wiley, 2021-03)
Idiopathic pulmonary fibrosis is a lethal lung fibrotic disease, associated with aging with a mean survival of 2-5 years and no curative treatment. The GSE4 peptide is able to rescue cells from senescence, DNA and oxidative ...
Nanostructured Lipid Carriers for Delivery of Chemotherapeutics: A Review
(MDPI, 2020-03-23)
The efficacy of current standard chemotherapy is suboptimal due to the poor solubility and short half-lives of chemotherapeutic agents, as well as their high toxicity and lack of specificity which may result in severe side ...
iPSC-Derived Intestinal Organoids from Cystic Fibrosis Patients Acquire CFTR Activity upon TALEN-Mediated Repair of the p.F508del Mutation
(Cell Press, 2020-06-12)
Cystic fibrosis (CF) is the main genetic cause of death among the Caucasian population. The disease is characterized by abnormal fluid and electrolyte mobility across secretory epithelia. The first manifestations occur ...
Towards brain-tissue-like biomaterials
(Nature, 2020-07-09)
Many biomaterials have been developed which aim to match the elastic modulus of the brain for improved interfacing. However, other properties such as ultimate toughness, tensile strength, poroviscoelastic responses, energy ...
Application of green nanoscience to olive polyphenols: Formulation design and biological evaluation of oleuropein-loaded nanstructured lipid carriers
(2020-11-06)
Esta tesis doctoral nace del interés de BIOSASUN en el desarrollo de formulaciones novedosas como solución a las limitaciones que presentan los polifenoles del olivo. Ello, unido a la especialidad del Grupo Nanobiocel en ...
Cost-Effectiveness Analysis of Text Messaging to Support Health Advice for Smoking Cessation
(BioMed Central, 2021-02-15)
Background: Smoking in one of the most serious public health problems. It is well known that it constitutes a major risk factor for chronic diseases and the leading cause of preventable death worldwide. Due to high prevalence ...
Standardizing Salivary Lactoferrin Measurements to Obtain a Robust Diagnostic Biomarker for Alzheimer's Disease
(Wiley, 2021-05-02)
The search for new, robust, and reproducible biomarkers for Alzheimer's disease (AD) diagnosis is a challenge. We recently reported that salivary lactoferrin (Lf) could be presented as new biomarker candidate for AD, being ...
Cells, Materials, and Fabrication Processes for Cardiac Tissue Engineering
(Frontiers Media, 2020-08-11)
Cardiovascular disease is the number one killer worldwide, with myocardial infarction (MI) responsible for approximately 1 in 6 deaths. The lack of endogenous regenerative capacity, added to the deleterious remodelling ...
Plasma Rich in Growth Factors technology: characterization, regulatory framework, current trends and perspectives
(2020-12-18)
La tecnología de plasma rico en factores de crecimiento, PRGF (por sus siglas en inglés, Plasma Rich in Growth Factors) es una terapia biológica autóloga que utiliza los propios componentes de la sangre del paciente como ...
Extraction, Characterization and Incorporation of Hypericum scruglii Extract in Ad Hoc Formulated Phospholipid Vesicles Designed for the Treatment of Skin Diseases Connected with Oxidative Stress
(MDPI, 2020-10-23)
An extract of Hypericum scruglii, an endangered endemic plant of Sardinia (Italy), was prepared and characterized. It was loaded in special phospholipid vesicles, glycerosomes, which were modified by adding maltodextrin ...