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Glycosaminoglycans in human retinoblastoma cells: heparan sulfate, a modulator of the pigment epithelium-derived factor-receptor interactions
(BioMed Central, 2003-02-19)
BACKGROUND: Pigment epithelium-derived factor (PEDF) has binding affinity for cell-surface receptors in retinoblastoma cells and for glycosaminoglycans. We investigated the effects of glycosaminoglycans on PEDF-receptor ...
Selective Interaction of Syntaxin 1A with KCNQ2: Possible Implications for Specific Modulation of Presynaptic Activity
(Public Library Science,, 2009-08-13)
KCNQ2/KCNQ3 channels are the molecular correlates of the neuronal M-channels, which play a major role in the control of neuronal excitability. Notably, they differ from homomeric KCNQ2 channels in their distribution pattern ...
High Mitochondrial DNA Stability in B-Cell Chronic Lymphocytic Leukemia
(Public Library Science, 2009-11-18)
Background: Chronic Lymphocytic Leukemia (CLL) leads to progressive accumulation of lymphocytes in the blood, bone marrow, and lymphatic tissues. Previous findings have suggested that the mtDNA could play an important role ...
Development of appropriateness explicit criteria for cataract extraction by phacoemulsification
(BioMed Central, 2006-03)
Background: Consensus development techniques were used in the late 1980s to create explicit criteria for the appropriateness of cataract extraction. We developed a new appropriateness of indications tool for cataract ...
Global Self-Organization of the Cellular Metabolic Structure
(Public Library Science, 2008-08)
Background: Over many years, it has been assumed that enzymes work either in an isolated way, or organized in small catalytic groups. Several studies performed using "metabolic networks models'' are helping to understand ...
Validation of a screening questionnaire for hip and knee osteoarthritis in old people
(BioMed Central, 2007-08-23)
Background: To develop a sensitive and specific screening tool for knee and hip osteoarthritis in the general population of elderly people.
Methods: The Knee and Hip OsteoArthritis Screening Questionnaire (KHOA- SQ) was ...
The Number of Catalytic Elements Is Crucial for the Emergence of Metabolic Cores
(Public Library of Science, 2009-10-19)
Background: Different studies show evidence that several unicellular organisms display a cellular metabolic structure characterized by a set of enzymes which are always in an active state (metabolic core), while the rest ...
Differential Micro RNA Expression in PBMC from Multiple Sclerosis Patients
(Public Library of Science, 2009-07-20)
Differences in gene expression patterns have been documented not only in Multiple Sclerosis patients versus healthy controls but also in the relapse of the disease. Recently a new gene expression modulator has been identified: ...
A Review of Estimation of Distribution Algorithms in Bioinformatics
(Biomed Central, 2008-09-11)
Evolutionary search algorithms have become an essential asset in the algorithmic toolbox for solving high-dimensional optimization problems in across a broad range of bioinformatics problems. Genetic algorithms, the most ...
Identification of Horse Chestnut Coat Color Genotype Using SNaPshot
(Biomed Central, 2009-12-16)
BACKGROUND: The Cantabrian Coast horse breeds of the Iberian Peninsula have mainly black or bay colored coats, but alleles responsible for a chestnut coat color run in these breeds and occasionally, chestnut horses are ...