Browsing OpenAire by Author "Egia Mendikute, Leire"

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      Hypoxia Reduces Cell Attachment of SARS-CoV-2 Spike Protein by Modulating the Expression of ACE2, Neuropilin-1, Syndecan-1 and Cellular Heparan Sulfate 

      Prieto Fernández, Endika; Egia Mendikute, Leire; Vila Vecilla, Laura; Bosch, Alexandre; Barreira Manrique, Adrián; Lee, So Young; García del Río, Ana; Antoñana Vildosola, Asier; Jiménez Lasheras, Borja; Moreno Cugnon, Leire; Jiménez Barbero, Jesús ORCID; Berra Ramírez, Miren Edurne; Ereño Orbea, June; Palazón, Asís (Taylor & Francis, 2021-06-06)
      A main clinical parameter of COVID-19 pathophysiology is hypoxia. Here we show that hypoxia decreases the attachment of the receptor-binding domain (RBD) and the S1 subunit (S1) of the spike protein of SARS-CoV-2 to ...
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      Stromal oncostatin M cytokine promotes breast cancer progression by reprogramming the tumor microenvironment 

      Araujo, Angela M.; Abaurrea, Andrea; Azcoaga, Peio; López Velazco, Joanna I.; Manzano, Sara; Rodríguez Martínez, Javier; Rezola, Ricardo; Egia Mendikute, Leire; Valdés Mora, Fátima; Flores, Juana M.; Jenkins, Liam; Pulido, Laura; Osorio Querejeta, Iñaki; Fernández Nogueira, Patricia; Ferrari, Nicola; Viera, Cristina; Martín Martín, Natalia; Tzankov, Alexandar; Eppenberger Castori, Serenella; Álvarez López, Isabel; Urruticoechea, Ander; Bragado, Paloma; Coleman, Nicholas; Palazón, Asís; Carracedo Pérez, Arkaitz ORCID; Gallego Ortega, David; Calvo González, Fernando; Isacke, Clare M.; Caffarel, María M.; Lawrie, Charles (American Society of Clinical Investigation, 2022-04-01)
      [EN] The tumor microenvironment (TME) is reprogrammed by cancer cells and participates in all stages of tumor progression. The contribution of stromal cells to the reprogramming of the TME is not well understood. Here, we ...