dc.contributor.author | Álvarez, Francisco José | |
dc.contributor.author | Revuelta Aramberri, Miren | |
dc.contributor.author | Santaolalla Montoya, Francisco | |
dc.contributor.author | Álvarez Díaz, Antonia Ángeles | |
dc.contributor.author | Lafuente, Héctor | |
dc.contributor.author | Arteaga Cabeza, Olatz | |
dc.contributor.author | Alonso Alconada, Daniel | |
dc.contributor.author | Sánchez del Rey, Ana Salomé | |
dc.contributor.author | Hilario Rodríguez, Enrique | |
dc.contributor.author | Martínez Ibargüen, Agustín | |
dc.date.accessioned | 2016-04-18T12:06:08Z | |
dc.date.available | 2016-04-18T12:06:08Z | |
dc.date.issued | 2015-05-26 | |
dc.identifier.citation | PLOS ONE 10(5) : (2015) // Article ID e0126885 | es |
dc.identifier.issn | 1932-6203 | |
dc.identifier.uri | http://hdl.handle.net/10810/17930 | |
dc.description.abstract | Introduction
Hypoxia-ischemia (HI) is a major perinatal problem that results in severe damage to the brain impairing the normal development of the auditory system. The purpose of the present study is to study the effect of perinatal asphyxia on the auditory pathway by recording auditory brain responses in a novel animal experimentation model in newborn piglets.
Method
Hypoxia-ischemia was induced to 1.3 day-old piglets by clamping 30 minutes both carotid arteries by vascular occluders and lowering the fraction of inspired oxygen. We compared the Auditory Brain Responses (ABRs) of newborn piglets exposed to acute hypoxia/ischemia (n = 6) and a control group with no such exposure (n = 10). ABRs were recorded for both ears before the start of the experiment (baseline), after 30 minutes of HI injury, and every 30 minutes during 6 h after the HI injury.
Results
Auditory brain responses were altered during the hypoxic-ischemic insult but recovered 30-60 minutes later. Hypoxia/ischemia seemed to induce auditory functional damage by increasing I-V latencies and decreasing wave I, III and V amplitudes, although differences were not significant.
Conclusion
The described experimental model of hypoxia-ischemia in newborn piglets may be useful for studying the effect of perinatal asphyxia on the impairment of the auditory pathway. | es |
dc.description.sponsorship | This research has been supported by grants PS120852, PI061085, PS091900 from ISCIII-General SubDirectorate for Research Assessment and Promotion and the European Regional Development Funds and by grants from the Basque Country Government (IT773/13) and Fundacion Jesus de Gangoiti Barrera. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript | es |
dc.language.iso | eng | es |
dc.publisher | Public Library Science | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.subject | induced neuronal loss | es |
dc.subject | cell-death | es |
dc.subject | evoked potentials | es |
dc.subject | preterm lambs | es |
dc.subject | injury | es |
dc.subject | term | es |
dc.subject | infants | es |
dc.subject | cannabidiol | es |
dc.subject | cat | es |
dc.title | Effect of Neonatal Asphyxia on the Impairment of the Auditory Pathway by Recording Auditory Brainstem Responses in Newborn Piglets: A New Experimentation Model to Study the Perinatal Hypoxic-Ischemic Damage on the Auditory Syste | es |
dc.type | info:eu-repo/semantics/article | es |
dc.rights.holder | © 2015 Alvarez et al. This is an open
access article distributed under the terms of the
Creative Commons Attribution License, which permits
unrestricted use, distribution, and reproduction in any
medium, provided the original author and source are
credited. | es |
dc.relation.publisherversion | http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0126885#abstract0 | es |
dc.identifier.doi | 10.1371/journal.pone.0126885 | |
dc.departamentoes | Biología celular e histología | es_ES |
dc.departamentoes | Dermatología, oftalmología y otorrinolaringología | es_ES |
dc.departamentoeu | Zelulen biologia eta histologia | es_ES |
dc.departamentoeu | Dermatologia, oftalmologia eta otorrinolaringologia | es_ES |
dc.subject.categoria | AGRICULTURAL AND BIOLOGICAL SCIENCES | |
dc.subject.categoria | MEDICINE | |
dc.subject.categoria | BIOCHEMISTRY AND MOLECULAR BIOLOGY | |