Browsing ACHUCARRO by Issue Date
Now showing items 21-33 of 33
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Regulación de las GTPasas de la familia Ras y la viabilidad de neuronas dopaminérgicas en respuesta a la señalización purinérgica
(2015-07-27)El ATP es una molécula natural cuya liberación descontrolada puede elevar su concentración extracelular a rango mM y promover la estimulación de receptores purinérgicos. Se sabe que esta estimulación tiene efectos citotóxicos ... -
Neuronal Hyperactivity Disturbs ATP Microgradients, Impairs Microglial Motility, and Reduces Phagocytic Receptor Expression Triggering Apoptosis/Microglial Phagocytosis Uncoupling
(2016)Phagocytosis by microglia is tightly coupled to apoptosis, swiftly removing apoptotic cells and actively maintaining tissue homeostasis, but the neuronal hyperactivity associated with epilepsy disrupts the ATP gradients ... -
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Organotypic Cultures as a Model to Study Adult Neurogenesis in CNS Disorders
(Hindawi, 2016)Neural regeneration resides in certain specific regions of adult CNS. Adult neurogenesis occurs throughout life, especially from the subgranular zone of hippocampus and the subventricular zone, and can be modulated in ... -
Synaptic plasticity and spatial working memory are impaired in the CD mouse model of Williams-Beuren syndrome
(null, 2016)Mice heterozygous for a complete deletion (CD) equivalent to the most common deletion found in individuals with Williams-Beuren syndrome (WBS) recapitulate relevant features of the neurocognitive phenotype, such as ... -
Organotypic Cultures as a Model to Study Adult Neurogenesis in CNS Disorders
(null, 2016)Neural regeneration resides in certain specific regions of adult CNS. Adult neurogenesis occurs throughout life, especially from the subgranular zone of hippocampus and the subventricular zone, and can be modulated in ... -
The Link of Inflammation and Neurodegeneration in Progressive Multiple Sclerosis
(Biomed Central, 2016-05-24)Progressive multiple sclerosis (MS) is characterized clinically by the accumulation of neurological disability without unequivocal recovery. Understanding the mechanisms that determine entering in this stage of the disease ... -
Interacción entre quinasas y moléculas apoptóticas en la muerte oligodendroglial excitotóxica
(2016-05-27)El fenómeno de excitotoxicidad glutamatérgica supone una de las causas subyacentes de multitud de enfermedades neurodegenerativas y afecta, entre otros tipos celulares, a los oligodendrocitos. Precisamente la vulnerabilidad ... -
The role of purinergic receptor A1 in neurogenesis modulation from subventricular zone
(2016-06-16)La neurogénesis continúa en la edad adulta en regiones específicas del cerebro como la zona subgranular del hipocampo y la zona subventricular (SVZ) de los ventrículos laterales. Resultados previos de nuestro laboratorio ... -
Effects of FTY720 on brain neurogenic niches in vitro and after kainic acid-induced injury
(Biomed Central, 2017-07-24)Background: FTY720 (fingolimod, Gilenya (TM)) is an oral, blood-brain barrier (BBB)-passing drug approved as immunomodulatory treatment for relapsing-remitting form of the multiple sclerosis (MS). In addition, FTY720 exerts ... -
Inflammation in stroke: the role of cholinergic, purinergic and glutamatergic signaling
(2018-05-04)The inflammatory response is a major factor in stroke pathophysiology and contributes to secondary neuronal damage in both acute and chronic stages of the ischemic injury. Recent work in experimental cerebral ischemia has ... -
A beta oligomers promote oligodendrocyte differentiation and maturation via integrin beta 1 and Fyn kinase signaling
(Nature Publishing Group, 2019-06-06)Alzheimer's disease (AD) is characterized by a progressive cognitive decline that correlates with the levels of amyloid beta-peptide (A beta) oligomers. Strong evidences connect changes of oligodendrocyte function with the ... -
A Natural Alternative Treatment for Urinary Tract Infections: Itxasol©, the Importance of the Formulation
(MDPI, 2021-07-28)Genito-urinary tract infections have a high incidence in the general population, being more prevalent among women than men. These diseases are usually treated with antibiotics, but very frequently, they are recurrent and ...