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Palladium-Catalyzed Dehydrogenative Coupling: An Efficient Synthetic Strategy for the Construction of the Quinoline Core

dc.contributor.authorCarral Menoyo, Asier
dc.contributor.authorOrtiz de Elguea Flecha, Verónica
dc.contributor.authorMartínez Nunes, Mikel ORCID
dc.contributor.authorSotomayor Anduiza, María Nuria
dc.contributor.authorLete Expósito, María Esther
dc.date.accessioned2018-04-09T08:49:40Z
dc.date.available2018-04-09T08:49:40Z
dc.date.issued2017-09
dc.identifier.citationMarine Drugs 15(9) : (2017) // Article ID 276es_ES
dc.identifier.issn1660-3397
dc.identifier.urihttp://hdl.handle.net/10810/26168
dc.description.abstractPalladium-catalyzed dehydrogenative coupling is an efficient synthetic strategy for the construction of quinoline scaffolds, a privileged structure and prevalent motif in many natural and biologically active products, in particular in marine alkaloids. Thus, quinolines and 1,2-dihydroquinolines can be selectively obtained in moderate-to-good yields via intramolecular C-H alkenylation reactions, by choosing the reaction conditions. This methodology provides a direct method for the construction of this type of quinoline through an efficient and atom economical procedure, and constitutes significant advance over the existing procedures that require preactivated reaction partners.es_ES
dc.description.sponsorshipMinisterio de Economia y Competitividad (CTQ2013-41229-P, CTQ2016-74881-P), Gobierno Vasco (IT1045-16) and Universidad del Pais Vasco/Euskal Herriko Unibertsitatea UPV/EHU are gratefully acknowledged for their financial support. V.O.-d.-E., A.C.-M. wish to thank Gobierno Vasco for grants. Technical and human support provided by Servicios Generales de Investigacion SGIker (UPV/EHU, MINECO, GV/EJ, ERDF and ESF) is also acknowledged.es_ES
dc.language.isoenges_ES
dc.publisherMDPIes_ES
dc.relationinfo:eu-repo/grantAgreement/MINECO/CTQ2013-41229-Pes_ES
dc.relationinfo:eu-repo/grantAgreement/MINECO/CTQ2016-74881-Pes_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.subjectquinolinees_ES
dc.subjectsynthesises_ES
dc.subjectpalladiumes_ES
dc.subjectcouplinges_ES
dc.subjectC-H alkenylationes_ES
dc.subjectmarine natural-productses_ES
dc.subjectC-H functionalizationes_ES
dc.subjectpyridoacridine alkalloidses_ES
dc.subjectbond functionalizationes_ES
dc.subjectindole-derivativeses_ES
dc.subjectalkenylationes_ES
dc.subjectheterocycleses_ES
dc.subjectolefinationes_ES
dc.subjectcyclizationes_ES
dc.subjectselectivityes_ES
dc.titlePalladium-Catalyzed Dehydrogenative Coupling: An Efficient Synthetic Strategy for the Construction of the Quinoline Corees_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.holder© 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).es_ES
dc.rights.holderAtribución 3.0 España*
dc.relation.publisherversionhttp://www.mdpi.com/1660-3397/15/9/276es_ES
dc.identifier.doi10.3390/md15090276
dc.departamentoesQuímica orgánica IIes_ES
dc.departamentoeuKimika organikoa IIes_ES


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© 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
Except where otherwise noted, this item's license is described as © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).