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Prevention of diabetes in overweight/obese children through a family based intervention program including supervised exercise (PREDIKID project): study protocol for a randomized controlled trial
dc.contributor.author | Arenaza, Lide | |
dc.contributor.author | Medrano Echeverría, María | |
dc.contributor.author | Amasene Ugalde, María | |
dc.contributor.author | Rodríguez-Vigil, Beatriz | |
dc.contributor.author | Díez, Ignacio | |
dc.contributor.author | Graña Romay, Manuel María | |
dc.contributor.author | Tobalina Larrea, Ignacio | |
dc.contributor.author | Maiz Aldalur, Edurne | |
dc.contributor.author | Arteche, Edurne | |
dc.contributor.author | Larrarte, Eider | |
dc.contributor.author | Huybrechts, Inge | |
dc.contributor.author | Davis, Catherine L. | |
dc.contributor.author | Ruiz, Jonatan R. | |
dc.contributor.author | Ortega, Francisco B. | |
dc.contributor.author | Margareto, Javier | |
dc.contributor.author | Labayen Goñi, Idoya | |
dc.date.accessioned | 2018-05-25T12:36:33Z | |
dc.date.available | 2018-05-25T12:36:33Z | |
dc.date.issued | 2017-08-10 | |
dc.identifier.citation | Trials 18 : (2017) // Article ID 372 | es_ES |
dc.identifier.issn | 1745-6215 | |
dc.identifier.uri | http://hdl.handle.net/10810/27116 | |
dc.description.abstract | Background: The global pandemic of obesity has led to an increased risk for prediabetes and type-2 diabetes (T2D). The aims of the current project are: (1) to evaluate the effect of a 22-week family based intervention program, including supervised exercise, on insulin resistance syndrome (IRS) risk in children with a high risk of developing T2D and (2) to identify the profile of microRNA in circulating exosomes and in peripheral blood mononuclear cells in children with a high risk of developing T2D and its response to a multidisciplinary intervention program including exercise. Methods: A total of 84 children, aged 8-12 years, with a high risk of T2D will be included and randomly assigned to control (N = 42) or intervention (N = 42) groups. The control group will receive a family based lifestyle education and psycho-educational program (2 days/month), while the intervention group will attend the same lifestyle education and psycho-educational program plus the exercise program (3 days/week, 90 min per session including warm-up, moderate to vigorous aerobic activities, and strength exercises). The following measurements will be evaluated at baseline prior to randomization and after the intervention: fasting insulin, glucose and hemoglobin A1c; body composition (dual-energy X-ray absorptiometry); ectopic fat (magnetic resonance imaging); microRNA expression in circulating exosomes and in peripheral blood mononuclear cells (MiSeq; Illumina); cardiorespiratory fitness (cardiopulmonary exercise testing); dietary habits and physical activity (accelerometry). Discussion: Prevention and identification of children with a high risk of developing T2D could help to improve their cardiovascular health and to reduce the comorbidities associated with obesity. | es_ES |
dc.description.sponsorship | The current project was supported by the Spanish Ministry of Industry and Competitiveness (DEP2016-78377-R), by "Fondos Estructurales de la Union Europea (FEDER), Una manera de hacer Europa." and by the University of the Basque Country (GIU14/21). This work was also supported by grants from Spanish Ministry of Economy and Competitiveness (RYC-2010-05957; RYC-2011-09011), Spanish Ministry of Education, Culture and Sports (FPU14/03329) and by the Education, Linguistic Policy and Culture Department of the Government of the Basque Country (PRE_2016_1_0057). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Biomed Central | es_ES |
dc.relation | info:eu-repo/grantAgreement/MINECO/RYC-2010-05957 | es_ES |
dc.relation | info:eu-repo/grantAgreement/MINECO/RYC-2011-09011 | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.subject | type-2 diabetes | es_ES |
dc.subject | children | es_ES |
dc.subject | exercise | es_ES |
dc.subject | family based lifestyle intervention program | es_ES |
dc.subject | mirna | es_ES |
dc.subject | obese children | es_ES |
dc.subject | insulin-resistance | es_ES |
dc.subject | physical-activity | es_ES |
dc.subject | circulating micrornas | es_ES |
dc.subject | cardiorespiratory fitness | es_ES |
dc.subject | cardiovascular-disease | es_ES |
dc.subject | potential biomarkers | es_ES |
dc.subject | ethnic-differences | es_ES |
dc.subject | hepatic steatosis | es_ES |
dc.subject | young-adults | es_ES |
dc.title | Prevention of diabetes in overweight/obese children through a family based intervention program including supervised exercise (PREDIKID project): study protocol for a randomized controlled trial | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. | es_ES |
dc.rights.holder | Atribución 3.0 España | * |
dc.relation.publisherversion | https://trialsjournal.biomedcentral.com/articles/10.1186/s13063-017-2117-y | es_ES |
dc.identifier.doi | 10.1186/s13063-017-2117-y | |
dc.departamentoes | Farmacia y ciencias de los alimentos | es_ES |
dc.departamentoes | Personalidad, evaluación y tratamiento psicológico | es_ES |
dc.departamentoeu | Farmazia eta elikagaien zientziak | es_ES |
dc.departamentoeu | Nortasuna, balioespena eta psikologia tratamendua | es_ES |
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Bestelakorik adierazi ezean, itemaren baimena horrela deskribatzen da:This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.