Identification of a panel of serum protein markers in early stage of sepsis and its validation in a cohort of patients

Garcia-Obregon, Susana; Azkargorta, Mikel; Seijas, Iratxe; Pilar-Orive, Javier; Borrego, Francisco; Elortza, Felix; Boyano López, María Dolores; Astigarraga Aguirre, María Iciar

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2018-08

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Garcia-Obregon, Susana

Azkargorta, Mikel

Seijas, Iratxe

Pilar-Orive, Javier

Borrego, Francisco

Elortza, Felix

Boyano López, María Dolores

Astigarraga Aguirre, María Iciar

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Journal of Microbiology Immunology and Infection 51(4) : 465-472 (2018)

URI

http://hdl.handle.net/10810/30249

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Background: Sepsis is a life-threatening illness with a challenging diagnosis. Current serum biomarkers are not sensitive enough for diagnosis. With the aim of finding proteins associated with sepsis, serum protein profile was compared between patients and healthy donors and serum classical inflammatory proteins were analyzed in both groups. Methods: Serum protein profiles were characterized by two-dimensional electrophoresis (2DE). Identification of the proteins was carried out by mass spectrophotometry and their validation was performed by Enzyme-Linked-lmmunoSorbent Assay (ELISA) in a cohort of 85 patients and 67 healthy donors. Seven classical inflammatory proteins were analyzed in the same cohort by ELISA: interleukin-2 receptor alpha-chain (sCD25), scavenger receptor cysteine-

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2017, Taiwan Society of Microbiology. Published by Elsevier Taiwan LLC. This is an open access article under the
CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

Bestelakorik adierazi ezean, itemaren baimena horrela deskribatzen da:2017, Taiwan Society of Microbiology. Published by Elsevier Taiwan LLC. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).