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Extracellular Vesicles in Hepatobiliary Malignancies

dc.contributor.authorLapitz Dambolenea, Ainhoa
dc.contributor.authorArbelaiz Cossio, Ander
dc.contributor.authorOlaizola Rebe, Paula
dc.contributor.authorAranburu, Aitziber
dc.contributor.authorBujanda Fernández de Pierola, Luis ORCID
dc.contributor.authorPerugorria Montiel, María Jesús
dc.contributor.authorBañales Asurmendi, Jesús María ORCID
dc.date.accessioned2018-12-20T14:07:45Z
dc.date.available2018-12-20T14:07:45Z
dc.date.issued2018-10-12
dc.identifier.citationFrontiers in Immunology 9 : (2018) // Article ID 2270es_ES
dc.identifier.issn1664-3224
dc.identifier.urihttp://hdl.handle.net/10810/30474
dc.description.abstractPrimary hepatobiliary malignancies include a heterogeneous group of cancers with dismal prognosis, among which hepatocellular carcinoma (HCC), cholangiocarcinoma (CCA), and hepatoblastoma (HB) stand out. These tumors mainly arise from the malignant transformation of hepatocytes, cholangiocytes (bile duct epithelial cells) or hepatoblasts (embryonic liver progenitor cells), respectively. Early diagnosis, prognosis prediction and effective therapies are still a utopia for these diseases. Extracellular vesicles (EVs) are small membrane-enclosed spheres secreted by cells and present in biological fluids. They contain multiple types of biomolecules, such as proteins, RNA, DNA, metabolites and lipids, which make them a potential source of biomarkers as well as regulators of human pathobiology. In this review, the role of EVs in the pathogenesis of hepatobiliary cancers and their potential usefulness as disease biomarkers are highlighted. Moreover, the therapeutic value of EV regulation is discussed and future directions on basic and clinical research are indicated.es_ES
dc.description.sponsorshipSpanish Ministries of Economy and Competitiveness [JB (FIS PI12/00380, FIS PI15/01132 and Miguel Servet Programme CON14/00129); MP (FIS PI14/00399, FIS PI17/00022) and Ramon y Cajal Programme RYC-2015-17755] cofinanced by Fondo Europeo de Desarrollo Regional (FEDER); ISCIII [CIBERehd: JB, LB, and MP], Spain; Diputacion Foral Gipuzkoa (JB: DFG15/010, DFG16/004), BIOEF (Basque Foundation for Innovation and Health Research: EiTB Maratoia BIO15/CA/016/BD to JB); Department of Health of the Basque Country (JB: 2013111173 and 2017111010; MP: 2015111100), and AECC Scientific Foundation (JB). AL and PO were funded by the Basque Government.es_ES
dc.language.isoenges_ES
dc.publisherFrontiers Mediaes_ES
dc.relationinfo:eu-repo/grantAgreement/MINECO/RYC-2015-17755es_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.subjectextracellular vesicleses_ES
dc.subjecthepatocellular carcinomaes_ES
dc.subjectcholangiocarcinomaes_ES
dc.subjecthepatoblastomaes_ES
dc.subjectpathogenesises_ES
dc.subjecttherapyes_ES
dc.subjectdiagnosises_ES
dc.subjectepithelial-mesenchymal transitiones_ES
dc.subjecthepatocellular-carcinoma cellses_ES
dc.subjectdendritic cellses_ES
dc.subjectcancer-celles_ES
dc.subjectintrahepatic cholangiocarcinomaes_ES
dc.subjectmultivesicular endosomeses_ES
dc.subjecttumor microenvironmentes_ES
dc.subjectpancreatic-canceres_ES
dc.subjectmediated transferes_ES
dc.subjectserum exosomeses_ES
dc.titleExtracellular Vesicles in Hepatobiliary Malignancieses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.holder2018 Lapitz, Arbelaiz, Olaizola, Aranburu, Bujanda, Perugorria and Banales. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.es_ES
dc.rights.holderAtribución 3.0 España*
dc.relation.publisherversionhttps://www.frontiersin.org/articles/10.3389/fimmu.2018.02270/fulles_ES
dc.identifier.doi10.3389/fimmu.2018.02270
dc.departamentoesMedicinaes_ES
dc.departamentoeuMedikuntzaes_ES


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2018 Lapitz, Arbelaiz, Olaizola, Aranburu, Bujanda, Perugorria and Banales. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Except where otherwise noted, this item's license is described as 2018 Lapitz, Arbelaiz, Olaizola, Aranburu, Bujanda, Perugorria and Banales. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.