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Novel Dextran-Supported Biological Probes Decorated with Disaccharide Entities for Investigating the Carbohydrate-Protein Interactions of Gal-3.
dc.contributor.author | Rahkila, Jani | |
dc.contributor.author | Ekholm, Filip S. | |
dc.contributor.author | Ardá, Ana | |
dc.contributor.author | Delgado, Sandra | |
dc.contributor.author | Savolainen, Johannes | |
dc.contributor.author | Jiménez Barbero, Jesús | |
dc.contributor.author | Leino, Reko | |
dc.date.accessioned | 2019-01-17T08:26:10Z | |
dc.date.available | 2019-01-17T08:26:10Z | |
dc.date.issued | 2018-11-30 | |
dc.identifier.citation | Chembiochem 19: 1-8 (2018) | es_ES |
dc.identifier.issn | 1439-7633 | |
dc.identifier.uri | http://hdl.handle.net/10810/30926 | |
dc.description.abstract | The quest for novel natural-like biomolecular probes that can be used to gain information on biological recognition events is of topical interest to several scientific areas. In particular, the recognition of carbohydrates by proteins modulates a number of important biological processes. These molecular recognition events are, however, difficult to study by the use of naturally occurring oligosaccharides and polysaccharides owing to their intrinsic structural heterogeneity and to the many technical difficulties encountered during the isolation of sufficient quantities of pure material for detailed structural and biological studies. Therefore, the construction of homogenous biomolecular probes that can mimic both the biophysical properties of polysaccharide backbones and the properties of bioactive oligosaccharide fragments are highly sought after. Herein, synthetic methodology for the construction of well-defined bioconjugates consisting of biologically relevant disaccharide fragments grafted onto a dextran backbone is presented, and a preliminary NMR spectroscopy study of their interactions with galectin-3 as a model lectin is conducted. | es_ES |
dc.description.sponsorship | The authors thank the Magnus Ehrnrooth foundation, the Ruth and Nils‐Erik Stenbäck foundation, Åbo Akademi University, and Turku Centre for Lifespan Research for financial support. Jarl Hemming at the Laboratory of Wood and Paper Chemistry at Åbo Akademi is thanked for technical assistance with the SEC/MALLS analysis. Leena Kaven‐Honka is thanked for preparing the C. albicans mannans. The group at CIC bioGUNE thanks Agencia Estatal de Investigacion and MINECO of Spain (CTQ2015‐64597‐C2‐1P and SEV‐2016‐0644 Severo Ochoa Excellence Acreditation) and the European Commission for the TOLLerant and GlycoVAX ITN projects. The authors acknowledge Prof. Francisco Javier Cañada‐Vicinay and Pablo Valverde for the acquisition of some NMR spectra and Dr. Filipa Marcelo for the generous gift of the plasmid of the hGal3 CRD. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Wiley | es_ES |
dc.relation | info:eu-repo/grantAgreement/MINECO/CTQ2015-64597-C2-1P | es_ES |
dc.relation | info:eu-repo/grantAgreement/MINECO/SEV-2016-0644 Severo Ochoa Excellence Acreditation | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/3.0/es/ | * |
dc.subject | NMR spectroscopy | es_ES |
dc.subject | carbohydrates | es_ES |
dc.subject | glycomimetics | es_ES |
dc.subject | molecular recognition | es_ES |
dc.subject | polysaccharides | es_ES |
dc.title | Novel Dextran-Supported Biological Probes Decorated with Disaccharide Entities for Investigating the Carbohydrate-Protein Interactions of Gal-3. | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | 2018 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. This is an open access article under the terms of the Creative Commons Attribution Non-Commercial License, which permits use, distribution and re- production in any medium, provided the original work is properly cited and is not used for commercial purposes. Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) | es_ES |
dc.rights.holder | Atribución-NoComercial 3.0 España | * |
dc.relation.publisherversion | https://onlinelibrary.wiley.com/doi/full/10.1002/cbic.201800423 | es_ES |
dc.identifier.doi | 10.1002/cbic.201800423 | |
dc.departamentoes | Química orgánica II | es_ES |
dc.departamentoeu | Kimika organikoa II | es_ES |
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This is an open access article under the terms of the Creative Commons
Attribution Non-Commercial License, which permits use, distribution and re-
production in any medium, provided the original work is properly cited and
is not used for commercial purposes. Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)