Metal-catalyzed C–H functionalization processes upon “click”-triazole assistance

Abstract

The functionalization of otherwise unreactive C–H bonds holds great promise for reducing the reliance on existing functional groups while improving energy efficiency and atom-economy. One of the most powerful strategies exploits chelation assistance through reversible coordination with metal catalysts. This microreview summarizes the most recent advances on the use of 1,2,3-triazoles as versatile directing groups in the field of C-H functionalization. The main feature relies on the modular and straightforward assembly of the required triazoles upon “click” chemistry and hence such procedures constitute practical synthetic tools of utmost importance for the late-stage diversification of “click compounds”, which are prevalent moieties in drug discovery and material science