Cross-Dehydrogenative Coupling Reactions for the Functionalization of α-Amino Acid Derivatives and Peptides

Abstract

The functionalization of typically unreactive C(sp3)–H bondsholds great promise for reducing the reliance on existing functionalgroups while improving atom-economy and energy efficiency. As a re-sult, this topic is a matter of genuine concern for scientists in order toachieve greener chemical processes. The site-specific modification of α-amino acid and peptides based upon C(sp3)–H functionalization stillrepresents a great challenge of utmost synthetic importance. This shortreview summarizes the most recent advances in ‘Cross-Dehydrogenative Couplings’ of α-amino carbonyl compounds and peptide derivativeswith a variety of nucleophilic coupling partners.