Multigeruza polimerikoak: mediku-protesietarako materialen ezaugarriak hobetzeko bidea

Abstract

Biomedikuntza arloan inplante moduan erabiltzeko material berrien es-kaera handia dago, baina errefus arazoak sortzen dituzte biobateragarritasun kontuak direla eta.Lan honetan azalduko dugu nola eraldatu dugun bi substratu motaren gainazala. Bat ezorganikoa izango da eta bestea polimerikoa. Geruzaz geruzako ("layer by layer") estrategiaz baliatuta, azido hialuroniko eta kitosanozko multigeruzak sortuko dira.Kitosanoa fluoreszenteki markatu eta mikroskopio konfokalean fluoreszentzia-haz kun dea behatu ondoren, ondorioztatu da geruzak modu arrakastatsu batean sortu direla. Honi esker, materialaren hidrofilitatea areagotzea lortu da, eta horrela, bakte-rioen aurkako gainazala lortzeaz gainera materialaren biobateragarritasuna handituko da modu merke eta sinple batean.; There is a great demand for new materials in the field of biomedicine to be used as implants, however they cause rejection problems due to their lack of biocom-patibility. In this work two substrates (inorganic and polymeric) will be surface modi-fied using the layer by layer strategy (LbL), in order to construct hyaluronic and chi-tosan multilayers. It has been proven that the layers were successfully built by fluorescent confocal microscopy by means of the increase of fluorescence along layers deposition after fluorescent labelling of chitosan. Thanks to this, it has been possible to increase the hydrophilicity of the surfaces enhancing antibacterial properties and get-ting more biocompatible materials in a simple and inexpensive way.