3D Cytocompatible Composites of PCL/Magnetite
dc.contributor.author | Díaz Tajada, Esperanza | |
dc.contributor.author | Valle García, María Blanca | |
dc.contributor.author | Ribeiro, Sylvie | |
dc.contributor.author | Lanceros Méndez, Senentxu | |
dc.contributor.author | Barandiarán García, José Manuel | |
dc.date.accessioned | 2020-02-06T18:06:07Z | |
dc.date.available | 2020-02-06T18:06:07Z | |
dc.date.issued | 2019-11-21 | |
dc.identifier.citation | Materials 12(23) : (2019) // Article ID 3843 | es_ES |
dc.identifier.issn | 1996-1944 | |
dc.identifier.uri | http://hdl.handle.net/10810/40490 | |
dc.description.abstract | A study of Magnetite (Fe3O4)as a suitable matrix for the improved adhesion and proliferation of MC3T3-E1 pre-osteoblast cells in bone regeneration is presented. Biodegradable and magnetic polycaprolactone (PCL)/magnetite (Fe3O4) scaffolds, which were fabricated by Thermally Induced Phase Separation, are likewise analyzed. Various techniques are used to investigate in vitro degradation at 37 °C, over 104 weeks, in a phosphate buffered saline (PBS) solution. Magnetic measurements that were performed at physiological temperature (310 K) indicated that degradation neither modified the nature nor the distribution of the magnetite nanoparticles. The coercive field strength of the porous matrices demonstrated ferromagnetic behavior and the probable presence of particle interactions. The added nanoparticles facilitated the absorption of PBS, with no considerable increase in matrix degradation rates, as shown by the Gel Permeation Chromatography (GPC) results for Mw, Mn, and I. There was no collapse of the scaffold structures that maintained their structural integrity. Their suitability for bone regeneration was also supported by the absence of matrix cytotoxicity in assays, even after additions of up to 20% magnetite. | es_ES |
dc.description.sponsorship | This work was supported by the Spanish Ministry of Economy and Competitiveness (MINECO) through the project MAT2016-76039-C4-3-R (AEI/FEDER, UE) and from the Basque Government Industry Department under the ELKARTEK, HAZITEK and PIBA programs. Supported by the Portuguese Foundation for Science and Technology (FCT) in the framework of the Strategic Funding UID/FIS/04650/2013, project POCI-01-0145-FEDER-028237 and grant SFRH/BD/111478/2015 (S.R.) is acknowledged. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | MDPI | es_ES |
dc.relation | info:eu-repo/grantAgreement/MINECO/MAT2016-76039-C4-3-R | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | |
dc.subject | PCL | es_ES |
dc.subject | magnetite | es_ES |
dc.subject | scaffolds | es_ES |
dc.subject | magnetism | es_ES |
dc.subject | cytotoxicity | es_ES |
dc.subject | in vitro degradation | es_ES |
dc.title | 3D Cytocompatible Composites of PCL/Magnetite | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.date.updated | 2020-01-28T13:30:23Z | |
dc.rights.holder | © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/) | es_ES |
dc.relation.publisherversion | https://www.mdpi.com/1996-1944/12/23/3843 | es_ES |
dc.identifier.doi | 10.3390/ma12233843 | |
dc.departamentoes | Electricidad y electrónica | |
dc.departamentoes | Ingeniería Minera y Metalúrgica y Ciencia de los Materiales | |
dc.departamentoeu | Elektrizitatea eta elektronika | |
dc.departamentoeu | Meatze eta metalurgia ingeniaritza materialen zientzia |
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Except where otherwise noted, this item's license is described as © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/)