Reduced antioxidant defense in early onset first-episode psychosis: a case-control study
Fecha
2011Autor
Mico, Juan Antonio
Rojas Corrales, Maria Olga
Gibert Rahola, Juan
Parellada, Mara
Moreno, Dolores
Fraguas, David
Graell Berna, Montserrat
Castro Fornieles, Josefina
Soutullo, César
Arango, Celso
Otero, Soraya
Navarro, Ana
Baeza, Inmaculada
Metadatos
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BMC Psychiatry 11(26) : (2011)
Resumen
Background
Our objective is to determine the activity of the antioxidant defense system at admission in patients with early onset first psychotic episodes compared with a control group.
Methods
Total antioxidant status (TAS) and lipid peroxidation (LOOH) were determined in plasma. Enzyme activities and total glutathione levels were determined in erythrocytes in 102 children and adolescents with a first psychotic episode and 98 healthy controls.
Results
A decrease in antioxidant defense was found in patients, measured as decreased TAS and glutathione levels. Lipid damage (LOOH) and glutathione peroxidase activity was higher in patients than controls. Our study shows a decrease in the antioxidant defense system in early onset first episode psychotic patients.
Conclusions
Glutathione deficit seems to be implicated in psychosis, and may be an important indirect biomarker of oxidative stress in early-onset schizophrenia. Oxidative damage is present in these patients, and may contribute to its pathophysiology.