Disrupted salience network dynamics in Parkinson's disease patients with impulse control disorders
Fecha
2020Autor
Navalpotro-Gomez, Irene
Kim, Jinhee
Paz-Alonso, Pedro M.
Delgado-Alvarado, Manuel
Quiroga-Varela, Ana
Jimenez-Urbieta, Haritz
Carreiras, Manuel
Strafella, Antonio P.
Rodriguez-Oroz, Maria Cruz
Metadatos
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Irene Navalpotro-Gomez, Jinhee Kim, Pedro M. Paz-Alonso, Manuel Delgado-Alvarado, Ana Quiroga-Varela, Haritz Jimenez-Urbieta, Manuel Carreiras, Antonio P. Strafella, Maria Cruz Rodriguez-Oroz, Disrupted salience network dynamics in Parkinson's disease patients with impulse control disorders, Parkinsonism & Related Disorders, Volume 70, 2020, Pages 74-81, ISSN 1353-8020, https://doi.org/10.1016/j.parkreldis.2019.12.009.
Resumen
Background: Dynamic functional network analysis may add relevant information about the temporal nature of
the neurocognitive alterations in PD patients with impulse control disorders (PD-ICD). Our aim was to investigate
changes in dynamic functional network connectivity (dFNC) in PD-ICD patients, and topological
properties of such networks.
Methods: Resting state fMRI was performed on 16 PD PD-ICD patients, 20 PD patients without ICD and 17
healthy controls, whose demographic, clinical and behavioral scores were assessed. We conducted a group
spatial independent component analysis, sliding window and graph-theory analyses.
Results: PD-ICD patients, in contrast to PD-noICD and HC subjects, were engaged across time in a brain configuration
pattern characterized by a lack of between-network connections at the expense of strong withinnetwork
connections (State III) in temporal, frontoinsular and cingulate cortices, all key nodes of the salience
network. Moreover, this increased maintenance of State III in PD-ICD patients was positively correlated with the
severity of impulsivity and novelty seeking as measured by specific scales. While in State III, these patients also
exhibited increased local efficiency in all the aforementioned areas.
Conclusions: Our findings show for the first time that PD-ICD patients have a dynamic functional engagement of
local connectivity involving the limbic circuit, leading to the inefficient modulation in emotional processing and
reward-related decision-making. These results provide new insights into the pathophysiology of ICD in PD patients
and indicate that the dFC study of fMRI could be a useful biomarker to identify patients at risk to develop
ICD.