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Disrupted salience network dynamics in Parkinson's disease patients with impulse control disorders
dc.contributor.author | Navalpotro-Gomez, Irene | |
dc.contributor.author | Kim, Jinhee | |
dc.contributor.author | Paz-Alonso, Pedro M. | |
dc.contributor.author | Delgado-Alvarado, Manuel | |
dc.contributor.author | Quiroga-Varela, Ana | |
dc.contributor.author | Jimenez-Urbieta, Haritz | |
dc.contributor.author | Carreiras, Manuel | |
dc.contributor.author | Strafella, Antonio P. | |
dc.contributor.author | Rodriguez-Oroz, Maria Cruz | |
dc.date.accessioned | 2020-03-26T07:10:25Z | |
dc.date.available | 2020-03-26T07:10:25Z | |
dc.date.issued | 2020 | |
dc.identifier.citation | Irene Navalpotro-Gomez, Jinhee Kim, Pedro M. Paz-Alonso, Manuel Delgado-Alvarado, Ana Quiroga-Varela, Haritz Jimenez-Urbieta, Manuel Carreiras, Antonio P. Strafella, Maria Cruz Rodriguez-Oroz, Disrupted salience network dynamics in Parkinson's disease patients with impulse control disorders, Parkinsonism & Related Disorders, Volume 70, 2020, Pages 74-81, ISSN 1353-8020, https://doi.org/10.1016/j.parkreldis.2019.12.009. | es_ES |
dc.identifier.issn | 1353-8020 | |
dc.identifier.uri | http://hdl.handle.net/10810/42352 | |
dc.description | Available online 16 December2019 | es_ES |
dc.description.abstract | Background: Dynamic functional network analysis may add relevant information about the temporal nature of the neurocognitive alterations in PD patients with impulse control disorders (PD-ICD). Our aim was to investigate changes in dynamic functional network connectivity (dFNC) in PD-ICD patients, and topological properties of such networks. Methods: Resting state fMRI was performed on 16 PD PD-ICD patients, 20 PD patients without ICD and 17 healthy controls, whose demographic, clinical and behavioral scores were assessed. We conducted a group spatial independent component analysis, sliding window and graph-theory analyses. Results: PD-ICD patients, in contrast to PD-noICD and HC subjects, were engaged across time in a brain configuration pattern characterized by a lack of between-network connections at the expense of strong withinnetwork connections (State III) in temporal, frontoinsular and cingulate cortices, all key nodes of the salience network. Moreover, this increased maintenance of State III in PD-ICD patients was positively correlated with the severity of impulsivity and novelty seeking as measured by specific scales. While in State III, these patients also exhibited increased local efficiency in all the aforementioned areas. Conclusions: Our findings show for the first time that PD-ICD patients have a dynamic functional engagement of local connectivity involving the limbic circuit, leading to the inefficient modulation in emotional processing and reward-related decision-making. These results provide new insights into the pathophysiology of ICD in PD patients and indicate that the dFC study of fMRI could be a useful biomarker to identify patients at risk to develop ICD. | es_ES |
dc.description.sponsorship | This work was supported by the Carlos III Institute of Health [PI11/ 02109] and by the ERA-NET Neuron program [PIM2010ERN-00733]. I.N-G. held a Mobility of Research Staff 2017 grant [MV17/00015] from the Carlos III Institute of Health under the framework of a Rio Hortega 2016 grant [CM16/00033]. J.K. has no disclosures to declare. P.M.P-A was supported by grants from the Spanish Ministry of Economy and Competitiveness [MINECO, RYC-2014-15440 and PGC2018- 093408-B-I00], and Neuroscience Research Projects programme from the Fundación Tatiana Pérez de Guzmán el Bueno. BCBL acknowledges funding from the Basque Government through the BERC 2018–2021 program and by the Spanish State Research Agency through BCBL Severo Ochoa excellence accreditation [SEV-2015-0490]. A.P.S. is supported by the Canadian Institute of Health Research and Canada Research Chair program. M.C.R–O. received financial support for her research from national and local government institutions in Spain (Carlos III Institute of Health, Basque Country Government, Diputacion Foral Guipuzcoa and the Network Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED)). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Parkinsonism and Related Disorders | es_ES |
dc.relation | info:eu-repo/grantAgreement/MINECO/ RYC-2014-15440 | es_ES |
dc.relation | info:eu-repo/grantAgreement/MINECO/PGC2018-093408-B-I00 | es_ES |
dc.relation | info:eu-repo/grantAgreement/MINECO/SEV-2015-0490 | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | Parkinson's disease | es_ES |
dc.subject | Impulse control disorders | es_ES |
dc.subject | Dynamic functional connectivity | es_ES |
dc.subject | Graph theory | es_ES |
dc.subject | Salience network | es_ES |
dc.title | Disrupted salience network dynamics in Parkinson's disease patients with impulse control disorders | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | © 2019 Elsevier Ltd. All rights reserved. | es_ES |
dc.relation.publisherversion | https://www.sciencedirect.com/journal/parkinsonism-and-related-disorders | es_ES |
dc.identifier.doi | 10.1016/j.parkreldis.2019.12.009 |