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Endocannabinoid LTD in Accumbal D1 Neurons Mediates Reward-Seeking Behavior
dc.contributor.author | Bilbao, Ainhoa | |
dc.contributor.author | Neuhofer, Daniela | |
dc.contributor.author | Sepers, Marja | |
dc.contributor.author | Wei, Shou-peng | |
dc.contributor.author | Eisenhardt, Manuela | |
dc.contributor.author | Hertle, Sarah | |
dc.contributor.author | Lassalle, Olivier | |
dc.contributor.author | Ramos Uriarte, Almudena | |
dc.contributor.author | Puente Bustinza, Nagore | |
dc.contributor.author | Lerner, Raissa | |
dc.contributor.author | Thomazeau, Aurore | |
dc.contributor.author | Grandes Moreno, Pedro Rolando | |
dc.contributor.author | Lutz, Beat | |
dc.contributor.author | Manzoni, Olivier J. | |
dc.contributor.author | Spanagel, Rainer | |
dc.date.accessioned | 2020-06-23T07:31:30Z | |
dc.date.available | 2020-06-23T07:31:30Z | |
dc.date.issued | 2020-03-27 | |
dc.identifier.citation | iScience 23(3) : (2020) // Article ID UNSP 100951 | es_ES |
dc.identifier.issn | 2589-0042 | |
dc.identifier.uri | http://hdl.handle.net/10810/44121 | |
dc.description.abstract | The nucleus accumbens (NAc) plays a key role in drug-related behavior and natural reward learning. Synaptic plasticity in dopamine D1 and D2 receptor medium spiny neurons (MSNs) of the NAc and the endogenous cannabinoid (eCB) system have been implicated in reward seeking. However, the precise molecular and physiological basis of reward-seeking behavior remains unknown. We found that the specific deletion of metabotropic glutamate receptor 5 (mGluR5) in D1-expressing MSNs (D1(miR)m-GluR5 mice) abolishes eCB-mediated long-term depression (LTD) and prevents the expression of drug (cocaine and ethanol), natural reward (saccharin), and brain-stimulation-seeking behavior. In vivo enhancement of 2-arachidonoylglycerol (2-AG) eCB signaling within the NAc core restores both eCB-LTD and reward-seeking behavior in D1-(miR)mGluR5 mice. The data suggest a model where the eCB and glutamatergic systems of the NAc act in concert to mediate reward-seeking responses. | es_ES |
dc.description.sponsorship | We would like to thank Rick Bernardi for editing this manuscript and Anne Rohrbacher for tissue preparation. This work was supported by the BundesministeriumforBildung und Forschung (e:Med program; FKZ: 01ZX1311A and 01ZX1909, Spanagel et al., 2013) and the Deutsche Forschungsgemeinschaft (DFG, Germany) TRR265/A05 and SFB1158/B04. Work in O.J.M. laboratory is supported by INSERM. C.S. and R.L were supported by the DFG Research Unit FOR926 (central project CP1) and by the BMBF Consortium LOGIN. Funding for P.G.'s laboratory was provided by Red de TrastornosAdictivos, ISCIII ("RD16/0017/0012" to PG), co-funded by ERDF/ESF, "Investing in your future"; The Basque Government (IT1230-19) and MINECO/FEDER, UE (SAF2015-65034-R). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Cell Press | es_ES |
dc.relation | info:eu-repo/grantAgreement/MINECO/SAF2015-65034-R | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.subject | long-term depression | es_ES |
dc.subject | in-vivo exposure | es_ES |
dc.subject | ethanol-seeking | es_ES |
dc.subject | induced reinstatement | es_ES |
dc.subject | MGLUR5 receptors | es_ES |
dc.subject | relapse | es_ES |
dc.subject | glutamate | es_ES |
dc.subject | plasticity | es_ES |
dc.subject | lipase | es_ES |
dc.subject | rats | es_ES |
dc.title | Endocannabinoid LTD in Accumbal D1 Neurons Mediates Reward-Seeking Behavior | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | 2020 The Author(s).This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/ | es_ES |
dc.rights.holder | Atribución 3.0 España | * |
dc.relation.publisherversion | https://www.sciencedirect.com/science/article/pii/S2589004220301358?via%3Dihub | es_ES |
dc.identifier.doi | 10.1016/j.isci.2020.100951 | |
dc.departamentoes | Neurociencias | es_ES |
dc.departamentoeu | Neurozientziak | es_ES |