dc.contributor.author | Alegret Ramón, Nuria | |
dc.contributor.author | Domínguez Alfaro, Antonio | |
dc.contributor.author | Mecerreyes Molero, David | |
dc.date.accessioned | 2020-07-01T10:13:30Z | |
dc.date.available | 2020-07-01T10:13:30Z | |
dc.date.issued | 2019-01-14 | |
dc.identifier.citation | Biomacromolecules 20(1) : 73-89 (2019) | es_ES |
dc.identifier.issn | 1525-7797 | |
dc.identifier.uri | http://hdl.handle.net/10810/44788 | |
dc.description | Unformatted postprint. | es_ES |
dc.description.abstract | 3D scaffolds appear to be a cost-effective ultimate answer
for biomedical applications, facilitating rapid results while providing an
environment similar to in vivo tissue. These biomaterials offer large
surface areas for cell or biomaterial attachment, proliferation, biosensing
and drug delivery applications. Among 3D scaffolds, the ones based on
conjugated polymers (CPs) and natural nonconductive polymers
arranged in a 3D architecture provide tridimensionality to cellular
culture along with a high surface area for cell adherence and
proliferation as well electrical conductivity for stimulation or sensing.
However, the scaffolds must also obey other characteristics:
homogeneous porosity, with pore sizes large enough to allow cell
penetration and nutrient flow; elasticity and wettability similar to the
tissue of implantation; and a suitable composition to enhance cell−
matrix interactions. In this Review, we summarize the fabrication
methods, characterization techniques and main applications of conductive 3D scaffolds based on conductive polymers. The
main barrier in the development of these platforms has been the fabrication and subsequent maintenance of the third dimension
due to challenges in the manipulation of conductive polymers. In the last decades, different approaches to overcome these
barriers have been developed for the production of conductive 3D scaffolds, demonstrating a huge potential for biomedical
purposes. Finally, we present an overview of the emerging strategies developed to manufacture 3D conductive scaffolds, the
techniques used to fully characterize them, and the biomedical fields where they have been applied. | es_ES |
dc.description.sponsorship | This project has received funding from the European Union’s Horizon 2020 research and innovation program under the
Marie Sklodowska-Curie grant agreement No 753293, acronym NanoBEAT, and European Research Council by
Starting Grant Innovative Polymers for Energy Storage (iPes) 306250. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | ACS Publications | es_ES |
dc.relation | info:eu-repo/grantAgreement/EC/H2020/753293 | es_ES |
dc.relation | info:eu-repo/grantAgreement/EC/FP7/306250 | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | polypyrrole | es_ES |
dc.subject | PEDOT | es_ES |
dc.subject | PANi | es_ES |
dc.subject | biomedical applications | es_ES |
dc.subject | tissue engineering | es_ES |
dc.subject | drug delivery | es_ES |
dc.subject | electric stimulation | es_ES |
dc.subject | conjugated polymers | es_ES |
dc.title | 3D Scaffolds Based on Conductive Polymers for Biomedical Applications | es_ES |
dc.type | info:eu-repo/semantics/review | es_ES |
dc.rights.holder | © 2019 American Chemical Society | es_ES |
dc.relation.publisherversion | https://pubs.acs.org/doi/10.1021/acs.biomac.8b01382 | es_ES |
dc.identifier.doi | 10.1021/acs.biomac.8b01382 | |
dc.contributor.funder | European Commission | |
dc.departamentoes | Ciencia y tecnología de polímeros | es_ES |
dc.departamentoeu | Polimeroen zientzia eta teknologia | es_ES |