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Polysaccharide-Based In Situ Self-Healing Hydrogels for Tissue Engineering Applications
dc.contributor.author | Maiz Fernández, Sheila | |
dc.contributor.author | Pérez Álvarez, Leyre | |
dc.contributor.author | Ruiz Rubio, Leire | |
dc.contributor.author | Vilas Vilela, José Luis | |
dc.contributor.author | Lanceros Méndez, Senentxu | |
dc.date.accessioned | 2020-10-30T11:45:39Z | |
dc.date.available | 2020-10-30T11:45:39Z | |
dc.date.issued | 2020-10-01 | |
dc.identifier.citation | Polymers 12(10) : (2020) // Article ID 2261 | es_ES |
dc.identifier.issn | 2073-4360 | |
dc.identifier.uri | http://hdl.handle.net/10810/47527 | |
dc.description.abstract | In situ hydrogels have attracted increasing interest in recent years due to the need to develop effective and practical implantable platforms. Traditional hydrogels require surgical interventions to be implanted and are far from providing personalized medicine applications. However, in situ hydrogels offer a wide variety of advantages, such as a non-invasive nature due to their localized action or the ability to perfectly adapt to the place to be replaced regardless the size, shape or irregularities. In recent years, research has particularly focused on in situ hydrogels based on natural polysaccharides due to their promising properties such as biocompatibility, biodegradability and their ability to self-repair. This last property inspired in nature gives them the possibility of maintaining their integrity even after damage, owing to specific physical interactions or dynamic covalent bonds that provide reversible linkages. In this review, the different self-healing mechanisms, as well as the latest research on in situ self-healing hydrogels, is presented, together with the potential applications of these materials in tissue regeneration. | es_ES |
dc.description.sponsorship | This research was funded by the Spanish State Research Agency (AEI) and the European Regional Development Fund (ERFD) through the project PID2019-106099RB-C43/AEI/10.13039/501100011033. Spanish Ministry of Economy and Competitiveness (MINECO) through the project MAT2016-76039-C4-3-R (AEI/FEDER, UE) and from the Basque Government Industry and Education Department under the ELKARTEK (KK-2020/00068, KK-2020/00099, KK2019/00039 and KK2019/00101), HAZITEK and PIBA (PIBA-2018-06) programs, respectively. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | MDPI | es_ES |
dc.relation | info:eu-repo/grantAgreement/MINECO/MAT2016-76039-C4-3-R | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | |
dc.subject | polysaccharide | es_ES |
dc.subject | self-healing | es_ES |
dc.subject | in situ hydrogels | es_ES |
dc.subject | dynamic bonds | es_ES |
dc.subject | injectability | es_ES |
dc.subject | tissue engineering | es_ES |
dc.title | Polysaccharide-Based In Situ Self-Healing Hydrogels for Tissue Engineering Applications | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.date.updated | 2020-10-26T14:24:07Z | |
dc.rights.holder | 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). | es_ES |
dc.relation.publisherversion | https://www.mdpi.com/2073-4360/12/10/2261/htm | es_ES |
dc.identifier.doi | 10.3390/polym12102261 | |
dc.departamentoes | Química física | |
dc.departamentoeu | Kimika fisikoa |
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Bestelakorik adierazi ezean, itemaren baimena horrela deskribatzen da:2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).