P2X7 Receptors as a Therapeutic Target in Cerebrovascular Diseases

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2020-06-18
Autor
Cisneros Mejorado, Abraham J.
Pérez Samartín, Alberto Luis ORCID
Domercq García, María ORCID
Arellano, Rogelio O.
Gottlieb, Miroslav
Koch Nolte, Friedrich
Matute Almau, Carlos José
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Frontiers in Molecular Neuroscience 13 : (2020) // Article ID 922
URI
http://hdl.handle.net/10810/48604
Resumen
Shortage of oxygen and nutrients in the brain induces the release of glutamate and ATP that can cause excitotoxicity and contribute to neuronal and glial damage. Our understanding of the mechanisms of ATP release and toxicity in cerebrovascular diseases is incomplete. This review aims at summarizing current knowledge about the participation of key elements in the ATP-mediated deleterious effects in these pathologies. This includes pannexin-1 hemichannels, calcium homeostasis modulator-1 (CALHM1), purinergic P2X7 receptors, and other intermediaries of CNS injury downstream of ATP release. Available data together with recent pharmacological developments in purinergic signaling may constitute a new opportunity to translate preclinical findings into more effective therapies in cerebrovascular diseases.
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2020 Cisneros-Mejorado, Pérez-Samartín, Domercq, Arellano, Gottlieb,Koch-Nolte and Matute. This is an open-access article distributed under the termsof the Creative Commons Attribution License (CC BY). The use, distribution orreproduction in other forums is permitted, provided the original author(s) and thecopyright owner(s) are credited and that the original publication in this journalis cited, in accordance with accepted academic practice. No use, distribution orreproduction is permitted which does not comply with these terms.
Excepto si se señala otra cosa, la licencia del ítem se describe como 2020 Cisneros-Mejorado, Pérez-Samartín, Domercq, Arellano, Gottlieb,Koch-Nolte and Matute. This is an open-access article distributed under the termsof the Creative Commons Attribution License (CC BY). The use, distribution orreproduction in other forums is permitted, provided the original author(s) and thecopyright owner(s) are credited and that the original publication in this journalis cited, in accordance with accepted academic practice. No use, distribution orreproduction is permitted which does not comply with these terms.