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P2X7 Receptors as a Therapeutic Target in Cerebrovascular Diseases

dc.contributor.authorCisneros Mejorado, Abraham J.
dc.contributor.authorPérez Samartín, Alberto Luis ORCID
dc.contributor.authorDomercq García, María ORCID
dc.contributor.authorArellano, Rogelio O.
dc.contributor.authorGottlieb, Miroslav
dc.contributor.authorKoch Nolte, Friedrich
dc.contributor.authorMatute Almau, Carlos José
dc.date.accessioned2020-11-26T11:00:27Z
dc.date.available2020-11-26T11:00:27Z
dc.date.issued2020-06-18
dc.identifier.citationFrontiers in Molecular Neuroscience 13 : (2020) // Article ID 922es_ES
dc.identifier.issn1662-5099
dc.identifier.urihttp://hdl.handle.net/10810/48604
dc.description.abstractShortage of oxygen and nutrients in the brain induces the release of glutamate and ATP that can cause excitotoxicity and contribute to neuronal and glial damage. Our understanding of the mechanisms of ATP release and toxicity in cerebrovascular diseases is incomplete. This review aims at summarizing current knowledge about the participation of key elements in the ATP-mediated deleterious effects in these pathologies. This includes pannexin-1 hemichannels, calcium homeostasis modulator-1 (CALHM1), purinergic P2X7 receptors, and other intermediaries of CNS injury downstream of ATP release. Available data together with recent pharmacological developments in purinergic signaling may constitute a new opportunity to translate preclinical findings into more effective therapies in cerebrovascular diseases.es_ES
dc.description.sponsorshipThis study was supported by grants from CONACYT-Mexico No. 252121 and PAPIITUNAM-Mexico No. IN203519 to ROA laboratory; by Spanish Ministry of Education and Science/FEDER (SAF2016-75292-R), Basque Government (IT1203/19), CIBERNED, Eranet-Neuron and Universidad del Pais Vasco to CM's laboratory. AC-M is a researcher from Catedras-CONACYT commissioned at Instituto de Neurobiologia at Universidad Nacional Autonoma de Mexico (UNAM).es_ES
dc.language.isoenges_ES
dc.publisherFrontiers Mediaes_ES
dc.relationinfo:eu-repo/grantAgreement/MINECO/SAF2016-75292-Res_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.subjectATPes_ES
dc.subjectpannexin-1es_ES
dc.subjectischemiaes_ES
dc.subjectneurones_ES
dc.subjectoligodendrocytees_ES
dc.subjecttumor-necrosis-factores_ES
dc.subjectprevents ATP excitotoxicityes_ES
dc.subjectoxygen-glucose deprivationes_ES
dc.subjectmicroglial activationes_ES
dc.subjectpannexin-1 channelses_ES
dc.subjectNLRP3 inflammasomEes_ES
dc.subjectIL-1-BETA releasees_ES
dc.subjectextracellular ATPes_ES
dc.subjectTNF-ALPHAes_ES
dc.subjectP2X(7)es_ES
dc.titleP2X7 Receptors as a Therapeutic Target in Cerebrovascular Diseaseses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.holder2020 Cisneros-Mejorado, Pérez-Samartín, Domercq, Arellano, Gottlieb,Koch-Nolte and Matute. This is an open-access article distributed under the termsof the Creative Commons Attribution License (CC BY). The use, distribution orreproduction in other forums is permitted, provided the original author(s) and thecopyright owner(s) are credited and that the original publication in this journalis cited, in accordance with accepted academic practice. No use, distribution orreproduction is permitted which does not comply with these terms.es_ES
dc.rights.holderAtribución 3.0 España*
dc.relation.publisherversionhttps://www.frontiersin.org/articles/10.3389/fnmol.2020.00092/fulles_ES
dc.identifier.doi10.3389/fnmol.2020.00092
dc.departamentoesNeurocienciases_ES
dc.departamentoeuNeurozientziakes_ES


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2020 Cisneros-Mejorado, Pérez-Samartín, Domercq, Arellano, Gottlieb,Koch-Nolte and Matute. This is an open-access article distributed under the termsof the Creative Commons Attribution License (CC BY). The use, distribution orreproduction in other forums is permitted, provided the original author(s) and thecopyright owner(s) are credited and that the original publication in this journalis cited, in accordance with accepted academic practice. No use, distribution orreproduction is permitted which does not comply with these terms.
Bestelakorik adierazi ezean, itemaren baimena horrela deskribatzen da:2020 Cisneros-Mejorado, Pérez-Samartín, Domercq, Arellano, Gottlieb,Koch-Nolte and Matute. This is an open-access article distributed under the termsof the Creative Commons Attribution License (CC BY). The use, distribution orreproduction in other forums is permitted, provided the original author(s) and thecopyright owner(s) are credited and that the original publication in this journalis cited, in accordance with accepted academic practice. No use, distribution orreproduction is permitted which does not comply with these terms.