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Advances in Microtechnology for Improved Cytotoxicity Assessment

dc.contributor.authorGarcía Hernando, Maite ORCID
dc.contributor.authorBenito López, Fernando ORCID
dc.contributor.authorBasabe Desmonts, Lourdes ORCID
dc.date.accessioned2021-03-16T16:41:11Z
dc.date.available2021-03-16T16:41:11Z
dc.date.issued2020-11-20
dc.identifier.citationFrontiers in Materials 7 : (2020) // Article ID 582030es_ES
dc.identifier.issn2296-8016
dc.identifier.urihttp://hdl.handle.net/10810/50655
dc.description.abstractIn vitro cytotoxicity testing is essential in the pharmaceutical and environmental industry to study the effects of potential harmful compounds for human health. Classical assays present several disadvantages: they are commonly based on live-death labelling, are highly time consuming and/or require skilled personnel to be performed. The current trend is to reduce the number of required cells and the time during the analysis, while increasing the screening capability and the accuracy and sensitivity of the assays, aiming single cell resolution. Microfabrication and surface engineering are enabling novel approaches for cytotoxicity assessment, offering high sensitivity and the possibility of automation in order to minimize user intervention. This review aims to overview the different microtechnology approaches available in this field, focusing on the novel developments for high-throughput, dynamic and real time screening of cytotoxic compounds.es_ES
dc.description.sponsorshipFunding support from: University of the Basque Country (PIF16/204), the funding support from Gobierno de España, Ministerio de Economía y Competitividad, with Grant No. BIO2016-80417-P (AEI/FEDER, UE) and Gobierno Vasco under grand IT1271-19.es_ES
dc.language.isoenges_ES
dc.publisherFrontiers Mediaes_ES
dc.relationinfo:eu-repo/grantAgreement/MINECO/BIO2016-80417-Pes_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.subjectmicrotechnologyes_ES
dc.subjectlab-on-a-chipes_ES
dc.subjectcytotoxicityes_ES
dc.subjectsurface engineeringes_ES
dc.subjectmicrofluidicses_ES
dc.subjectsensorses_ES
dc.subjectbiosensorses_ES
dc.subjectsingle celles_ES
dc.titleAdvances in Microtechnology for Improved Cytotoxicity Assessmentes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.holder© 2020 Garcia-Hernando, Benito-Lopez and Basabe-Desmonts. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.es_ES
dc.relation.publisherversionhttps://www.frontiersin.org/articles/10.3389/fmats.2020.582030/fulles_ES
dc.identifier.doi10.3389/fmats.2020.582030
dc.departamentoesQuímica analíticaes_ES
dc.departamentoesZoología y biología celular animales_ES
dc.departamentoeuKimika analitikoaes_ES
dc.departamentoeuZoologia eta animalia zelulen biologiaes_ES


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© 2020 Garcia-Hernando, Benito-Lopez and Basabe-Desmonts. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Except where otherwise noted, this item's license is described as © 2020 Garcia-Hernando, Benito-Lopez and Basabe-Desmonts. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.