The Role of lncRNAs in Gene Expression Regulation through mRNA Stabilization
dc.contributor.author | Sebastián de la Cruz, Maialen | |
dc.contributor.author | González Moro, Itziar | |
dc.contributor.author | Olazagoitia Garmendia, Ane | |
dc.contributor.author | Castellanos Rubio, Ainara | |
dc.contributor.author | Santín Gómez, Izortze | |
dc.date.accessioned | 2021-03-30T10:17:20Z | |
dc.date.available | 2021-03-30T10:17:20Z | |
dc.date.issued | 2021-01-05 | |
dc.identifier.citation | Non-Coding RNA 7(1) : (2021) // Article ID 3 | es_ES |
dc.identifier.issn | 2311-553X | |
dc.identifier.uri | http://hdl.handle.net/10810/50824 | |
dc.description.abstract | mRNA stability influences gene expression and translation in almost all living organisms, and the levels of mRNA molecules in the cell are determined by a balance between production and decay. Maintaining an accurate balance is crucial for the correct function of a wide variety of biological processes and to maintain an appropriate cellular homeostasis. Long non-coding RNAs (lncRNAs) have been shown to participate in the regulation of gene expression through different molecular mechanisms, including mRNA stabilization. In this review we provide an overview on the molecular mechanisms by which lncRNAs modulate mRNA stability and decay. We focus on how lncRNAs interact with RNA binding proteins and microRNAs to avoid mRNA degradation, and also on how lncRNAs modulate epitranscriptomic marks that directly impact on mRNA stability. | es_ES |
dc.description.sponsorship | LncRNA work in author’s laboratory is supported by European Foundation for the Study of Diabetes (EFSD)-EFSD/JDRF/Lilly Programme on Type 1 Diabetes Research and the Spanish Ministry of Science, Innovation and Universities (PID2019-104475GA-I00) to I.S; and Spanish Ministry of Science, Innovation and Universities (SAF2017-91873-EXP and PGC2018-097573-A-I00) to ACR. M.S.D. and I.G.M. are supported by a Predoctoral Fellowship Grant from the UPV/EHU (Universidad del País Vasco/Euskal Herriko Unibertsitatea) and A.O.G. is supported by a Predoctoral Fellowship Grant from the Education Department of Basque Government. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | MDPI | es_ES |
dc.relation | info:eu-repo/grantAgreement/MICINN/PID2019-104475GA-I00 | es_ES |
dc.relation | info:eu-repo/grantAgreement/MICINN/SAF2017-91873-EXP | es_ES |
dc.relation | info:eu-repo/grantAgreement/MICINN/PGC2018-097573-A-I00) to | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | |
dc.subject | long non-coding RNA | es_ES |
dc.subject | mRNA stability | es_ES |
dc.subject | RNA binding protein | es_ES |
dc.subject | microRNA | es_ES |
dc.subject | gene expression | es_ES |
dc.title | The Role of lncRNAs in Gene Expression Regulation through mRNA Stabilization | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.date.updated | 2021-03-26T14:06:33Z | |
dc.rights.holder | 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). | es_ES |
dc.relation.publisherversion | https://www.mdpi.com/2311-553X/7/1/3/htm | es_ES |
dc.identifier.doi | 10.3390/ncrna7010003 | |
dc.departamentoes | Genética, antropología física y fisiología animal | |
dc.departamentoeu | Genetika,antropologia fisikoa eta animalien fisiologia |
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Except where otherwise noted, this item's license is described as 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).