RNA Localization and Local Translation in Glia in Neurological and Neurodegenerative Diseases: Lessons from Neurons
dc.contributor.author | Blanco Urrejola, Maite | |
dc.contributor.author | Gaminde Blasco, Adhara Mikaela | |
dc.contributor.author | Gamarra, María | |
dc.contributor.author | De la Cruz Gambra, Aida | |
dc.contributor.author | Vecino Cordero, Elena | |
dc.contributor.author | Alberdi Alfonso, Elena María | |
dc.contributor.author | Baleriola, Jimena | |
dc.date.accessioned | 2021-03-31T08:00:04Z | |
dc.date.available | 2021-03-31T08:00:04Z | |
dc.date.issued | 2021-03-12 | |
dc.identifier.citation | Cells 10(3) : (2021) // Article ID 632 | es_ES |
dc.identifier.issn | 2073-4409 | |
dc.identifier.uri | http://hdl.handle.net/10810/50834 | |
dc.description.abstract | Cell polarity is crucial for almost every cell in our body to establish distinct structural and functional domains. Polarized cells have an asymmetrical morphology and therefore their proteins need to be asymmetrically distributed to support their function. Subcellular protein distribution is typically achieved by localization peptides within the protein sequence. However, protein delivery to distinct cellular compartments can rely, not only on the transport of the protein itself but also on the transport of the mRNA that is then translated at target sites. This phenomenon is known as local protein synthesis. Local protein synthesis relies on the transport of mRNAs to subcellular domains and their translation to proteins at target sites by the also localized translation machinery. Neurons and glia specially depend upon the accurate subcellular distribution of their proteome to fulfil their polarized functions. In this sense, local protein synthesis has revealed itself as a crucial mechanism that regulates proper protein homeostasis in subcellular compartments. Thus, deregulation of mRNA transport and/or of localized translation can lead to neurological and neurodegenerative diseases. Local translation has been more extensively studied in neurons than in glia. In this review article, we will summarize the state-of-the art research on local protein synthesis in neuronal function and dysfunction, and we will discuss the possibility that local translation in glia and deregulation thereof contributes to neurological and neurodegenerative diseases. | es_ES |
dc.description.sponsorship | This paper was partially funded by grants awarded to J.B. (MICINN grants SAF2016-76347-R, RYC-2016-19837 and PID2019-110721RB-I00; The Alzheimer’s Association grant AARG-19-618303) and E.A. (MICINN grant PID2019-108465RB-I00; Basque Government grant PIBA-2020-1-0012). M.B.-U. is a UPV/EHU fellow; A.G.-B. is a FPU (FPU17/04891) fellow; M.G. and A.d.l.C. are GV fellows. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | MDPI | es_ES |
dc.relation | info:eu-repo/grantAgreement/MICINN/SAF2016-76347-R | es_ES |
dc.relation | info:eu-repo/grantAgreement/MICINN/RYC-2016-19837 | es_ES |
dc.relation | info:eu-repo/grantAgreement/MICINN/PID2019-110721RB-I00 | es_ES |
dc.relation | info:eu-repo/grantAgreement/MICINN/PID2019-108465RB-I00 | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | |
dc.subject | mRNA transport and localization | es_ES |
dc.subject | local protein synthesis | es_ES |
dc.subject | neurons | es_ES |
dc.subject | neurites | es_ES |
dc.subject | glia | es_ES |
dc.subject | processes | es_ES |
dc.subject | neurological and neurodegenerative diseases | es_ES |
dc.title | RNA Localization and Local Translation in Glia in Neurological and Neurodegenerative Diseases: Lessons from Neurons | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.date.updated | 2021-03-26T14:07:08Z | |
dc.rights.holder | 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). | es_ES |
dc.relation.publisherversion | https://www.mdpi.com/2073-4409/10/3/632/htm | es_ES |
dc.identifier.doi | 10.3390/cells10030632 | |
dc.departamentoes | Neurociencias | |
dc.departamentoes | Biología celular e histología | |
dc.departamentoeu | Neurozientziak | |
dc.departamentoeu | Zelulen biologia eta histologia |
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Except where otherwise noted, this item's license is described as 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).