dc.contributor.author | Sanz Echevarría, María Begoña | |
dc.contributor.author | Arrieta Etxeberria, Haritz | |
dc.contributor.author | Rezola Pardo, Chloe | |
dc.contributor.author | Fernández Atucha, Ainhoa | |
dc.contributor.author | Garín Balerdi, Jon | |
dc.contributor.author | Arizaga Iribarren, Nagore | |
dc.contributor.author | Rodríguez Larrad, Ana | |
dc.contributor.author | Irazusta Astiazaran, Jon | |
dc.date.accessioned | 2021-06-03T11:26:37Z | |
dc.date.available | 2021-06-03T11:26:37Z | |
dc.date.issued | 2021-04-27 | |
dc.identifier.citation | Scientific Reports 11(1) : (2021) // Article ID 9098 | es_ES |
dc.identifier.issn | 2045-2322 | |
dc.identifier.uri | http://hdl.handle.net/10810/51743 | |
dc.description.abstract | Serum alpha-klotho (s-klotho) protein has been linked with lifespan, and low concentrations of s-klotho have been associated with worse physical and cognitive outcomes. Although its significance in aging remains unclear, s-klotho has been proposed as a molecular biomarker of frailty and dependence. This study is a secondary analysis of data from a clinical trial performed in a population of 103 older individuals living in 10 nursing homes in Gipuzkoa (Spain). We aimed to elucidate associations between s-klotho (as measured by enzyme-linked immunosorbent assay) and body composition, physical fitness, and cognition, as well as frailty and dependence (determined using validated tests and scales). In addition, we investigated the association of s-klotho concentration with falls in the six months following the initial assessment. Low s-klotho levels were associated with a lower score in the psychological component of the Tilburg Frailty Indicator, a worse score in the Coding Wechsler Adult Intelligence Scale, and a greater dependence in activities of daily living. Moreover, participants with lower s-klotho concentrations suffered more falls during the 6 months after the assessment. Future translational research should aim to validate klotho's putative role as a biomarker that could identify the risk of aging-related adverse events in clinical practice. | es_ES |
dc.description.sponsorship | This work was supported by grants from the Basque government (ELKARTEK15/39, ELKARTEK16/57, ELKARTEK17/61, RIS16/07, SAN17/11), the Euskampus Fundazioa Foundation, and the Convention between UPV/EHU and the Gipuzkoa Provincial Council (Gipuzkoa Eraikiz). Haritz Arrieta and Chloe Rezola were supported by two fellowships from the University of the Basque Country (UPV/EHU) | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Springer | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.subject | low plasma Klotho | es_ES |
dc.subject | Alpha-Klotho | es_ES |
dc.subject | older-adults | es_ES |
dc.subject | vitamin-D | es_ES |
dc.subject | physical performance | es_ES |
dc.subject | cerebrospinal-fluid | es_ES |
dc.subject | disability | es_ES |
dc.subject | mortality | es_ES |
dc.subject | FGF-23 | es_ES |
dc.subject | fate | es_ES |
dc.title | Low Serum Klotho Concentration is Associated with Worse Cognition, Psychological Components of Frailty, Dependence, and Falls in Nursing Home Residents | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | This article is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0) | es_ES |
dc.rights.holder | Atribución 3.0 España | * |
dc.relation.publisherversion | https://www.nature.com/articles/s41598-021-88455-6 | es_ES |
dc.identifier.doi | 10.1038/s41598-021-88455-6 | |
dc.departamentoes | Enfermería | es_ES |
dc.departamentoes | Enfermería II | es_ES |
dc.departamentoes | Fisiología | es_ES |
dc.departamentoeu | Erizaintza | es_ES |
dc.departamentoeu | Erizaintza II | es_ES |
dc.departamentoeu | Fisiologia | es_ES |