Extended Enolates: Versatile Intermediates for Asymmetric C-H Functionalization via Noncovalent Catalysis
dc.contributor.author | Oyarbide Garmendia, Juan Miguel | |
dc.contributor.author | Palomo Nicolau, Claudio | |
dc.date.accessioned | 2021-10-07T08:31:10Z | |
dc.date.available | 2021-10-07T08:31:10Z | |
dc.date.issued | 2021 | |
dc.identifier.citation | Chemistry-A European Journal 27(40) : 10226-10246 (2021) | es_ES |
dc.identifier.issn | 0947-6539 | |
dc.identifier.issn | 1521-3765 | |
dc.identifier.uri | http://hdl.handle.net/10810/53267 | |
dc.description.abstract | Catalyst-controlled functionalization of unmodified carbonyl compounds is a relevant operation in organic synthesis, especially when high levels of site- and stereo-selectivity can be attained. This objective is now within reach for some subsets of enolizable substrates using various types of activation mechanisms. Recent contributions to this area include enantioselective transformations that proceed via transiently generated noncovalent di(tri)enolate-catalyst coordination species. While relatively easier to form than simple enolate congeners, di(tri)enolates are ambifunctional in nature and so control of the reaction regioselectivity becomes an issue. This Minireview discusses in some detail this and other problems, and how noncovalent activation approaches based on metallic and metal free catalysts have been developed to advance the field. | es_ES |
dc.description.sponsorship | We thank the University of the Basque Country UPV/EHU (UFI QOSYC 11/22), the Basque Government (grant IT-1236-19) and Ministerio de Ciencia e Innovation (grant PID2019109633GB C21), Spain, for their continuous financial support. Document | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Wiley | es_ES |
dc.relation | info:eu-repo/grantAgreement/MICINN/PID2019109633GB C21 | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ | * |
dc.subject | asymmetric catalysis | es_ES |
dc.subject | Bronsted base catalysis | es_ES |
dc.subject | C-H functionalization | es_ES |
dc.subject | dienolates | es_ES |
dc.subject | regioselectivity | es_ES |
dc.subject | vinylogous michael addition | es_ES |
dc.subject | allylic-allylic alkylation | es_ES |
dc.subject | baylis-hillman carbonates | es_ES |
dc.subject | aldol reaction | es_ES |
dc.subject | 3-alkylidene oxindoles | es_ES |
dc.subject | enantioselective addition | es_ES |
dc.subject | olefinic azlactones | es_ES |
dc.subject | mannich reaction | es_ES |
dc.subject | alpha | es_ES |
dc.subject | ketones | es_ES |
dc.title | Extended Enolates: Versatile Intermediates for Asymmetric C-H Functionalization via Noncovalent Catalysis | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | 2021 The Authors. Chemistry - A European Journal published by Wiley- VCH GmbH. This is an open access article under the terms of the Creative Commons Attribution Non-Commercial NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made | es_ES |
dc.rights.holder | Atribución-NoComercial-SinDerivadas 3.0 España | * |
dc.relation.publisherversion | https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/chem.202100756 | es_ES |
dc.identifier.doi | 10.1002/chem.202100756 | |
dc.departamentoes | Química orgánica I | es_ES |
dc.departamentoeu | Kimika organikoa I | es_ES |
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Except where otherwise noted, this item's license is described as 2021 The Authors. Chemistry - A European Journal published by Wiley-
VCH GmbH. This is an open access article under the terms of the Creative
Commons Attribution Non-Commercial NoDerivs License, which permits use
and distribution in any medium, provided the original work is properly cited,
the use is non-commercial and no modifications or adaptations are made