Hydrogen sulphide-triggered theranostic prodrugs based on the dynamic chemistry of tetrazines

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Date
2022
Author
Perretti, Marcelle D.
Pérez Pérez, Yaiza
Soler Carracedo, Kevin
Martín Encinas, Endika
Alonso Pérez, Concepción Estibaliz ORCID
Scoccia, Jimena
Carrillo Fumero, Romen
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Chemical Communications 58 : 5518-5521 (2022)
URI
http://hdl.handle.net/10810/56467
Abstract
[EN] Dynamic nucleophilic aromatic substitution of tetrazines (S(N)Tz) has been employed to build theranostic prodrugs that are activated by hydrogen sulfide. H2S is typically found in high concentrations in some kinds of cancer cells and it is able to trigger the disassembly of tetrazine prodrugs. In such a way, a dual release of drugs and/or fluorescent compounds can be selectively triggered.
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This journal is © The Royal Society of Chemistry 2022. This article is licensed under a Creative Commons Attribution 3.0 Unported (CC BY 3.0)
Except where otherwise noted, this item's license is described as This journal is © The Royal Society of Chemistry 2022. This article is licensed under a Creative Commons Attribution 3.0 Unported (CC BY 3.0)