Contribution of cardio-vascular risk factors to depressive status in the PREDIMED-PLUS Trial. A cross-sectional and a 2-year longitudinal study
View/ Open
Date
2022-04-13Author
Martín-Peláez, Sandra
Serra Majem, Lluis
Cano Ibáñez, Naomi
Martínez González, Miguel Ángel
Salas Salvadó, Jordi
Corella, Dolores
Lassale, Camille
Martínez, J. Alfredo
Wärnberg, Julia
Vioque, Jesús
Romaguera, Dora
López Miranda, José
Estruch, Ramón
Tinahones, Francisco J.
Lapetra, José
Fernández Aranda, Fernando
Bueno Cavanillas, Aurora
Tur, Josep A.
Martín, Vicente
Pintó, Xavier
Delgado Rodríguez, Miguel
Matía Martín, Pilar
Vidal, Josep
Vázquez, Clotilde
Daimiel, Lidia
Ros, Emilio
Toledo, Estefanía
Nishi, Stephanie K.
Sorli, José Vicente
Malcampo, Mireia
Zulet, M. Ángeles
Moreno Rodríguez, Anai
Cueto Galán, Raquel
Vivancos Aparicio, Diego
Colom, Antoni
García Ríos, Antonio
Casas, Rosa
Bernal López, María Rosa
Santos Lozano, José Manuel
Váquez, Zenaida
Gómez Martínez, Carlos
Ortega Azorín, Carolina
Del ValI, José Luis
Abete, Itziar
Goikoetxea Bahon, Amaia
Pascual, Elena
Becerra Tomás, Nerea
Chillarón, Juan J.
Sánchez Villegas, Almudena
Metadata
Show full item record
PloSOne 17(4) : (2022) // Article ID e0265079
Abstract
BACKGROUND: Cardio-vascular disease and depression are thought to be closely related, due to shared risk factors. The aim of the study was to determine the association between cardio-vascular risk (CVR) factors and depressive status in a population (55-75 years) with metabolic syndrome (MetS) from the PREDIMED-Plus trial.
METHODS AND FINDINGS: Participants were classified into three groups of CVR according to the Framingham-based REGICOR function: (1) low (LR), (2) medium (MR) or (3) high/very high (HR). The Beck Depression Inventory-II (BDI-II) was used to assess depressive symptoms at baseline and after 2 years. The association between CVR and depressive status at baseline (n = 6545), and their changes after 2 years (n = 4566) were evaluated through multivariable regression models (logistic and linear models). HR women showed higher odds of depressive status than LR [OR (95% CI) = 1.78 (1.26, 2.50)]. MR and HR participants with total cholesterol <160 mg/mL showed higher odds of depression than LR [OR (95% CI) = 1.77 (1.13, 2.77) and 2.83 (1.25, 6.42) respectively)] but those with total cholesterol ≥280 mg/mL showed lower odds of depression than LR [OR (95% CI) = 0.26 (0.07, 0.98) and 0.23 (0.05, 0.95), respectively]. All participants decreased their BDI-II score after 2 years, being the decrease smaller in MR and HR diabetic compared to LR [adjusted mean±SE = -0.52±0.20, -0.41±0.27 and -1.25±0.31 respectively). MR and HR participants with total cholesterol between 240-279 mg/mL showed greater decreases in the BDI-II score compared to LR (adjusted mean±SE = -0.83±0.37, -0.77±0.64 and 0.97±0.52 respectively).
CONCLUSIONS: Improving cardiovascular health could prevent the onset of depression in the elderly. Diabetes and total cholesterol in individuals at high CVR, may play a specific role in the precise response. International Standard Randomized Controlled Trial (ISRCTN89898870).
Except where otherwise noted, this item's license is described as 2022 Martín-Peláez et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.