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Dynamic and Self-Healable Chitosan/Hyaluronic Acid-Based In Situ-Forming Hydrogels
dc.contributor.author | Maiz Fernández, Sheila | |
dc.contributor.author | Pérez Álvarez, Leyre | |
dc.contributor.author | Silván, Unai | |
dc.contributor.author | Vilas Vilela, José Luis | |
dc.contributor.author | Lanceros Méndez, Senentxu | |
dc.date.accessioned | 2022-08-31T10:00:00Z | |
dc.date.available | 2022-08-31T10:00:00Z | |
dc.date.issued | 2022-07-29 | |
dc.identifier.citation | Gels 8(8) : (2022) // Article ID 477 | es_ES |
dc.identifier.issn | 2310-2861 | |
dc.identifier.uri | http://hdl.handle.net/10810/57374 | |
dc.description.abstract | In situ-forming, biodegradable, and self-healing hydrogels, which maintain their integrity after damage, owing to dynamic interactions, are essential biomaterials for bioapplications, such as tissue engineering and drug delivery. This work aims to develop in situ, biodegradable and self-healable hydrogels based on dynamic covalent bonds between N-succinyl chitosan (S-CHI) and oxidized aldehyde hyaluronic acid (A-HA). A robust effect of the molar ratio of both S-CHI and A-HA was observed on the swelling, mechanical stability, rheological properties and biodegradation kinetics of these hydrogels, being the stoichiometric ratio that which leads to the lowest swelling factor (×12), highest compression modulus (1.1·10−3 MPa), and slowest degradation (9 days). Besides, a rapid (3 s) self-repairing ability was demonstrated in the macro scale as well as by rheology and mechanical tests. Finally, the potential of these biomaterials was evidenced by cytotoxicity essay (>85%). | es_ES |
dc.description.sponsorship | This research was funded by Spanish State Research Agency (AEI) and the European Regional Development Fund (ERFD) through the project PID2019-106099RB-C43/AEI/10.13039/501100011033, as well as from the Basque Government Industry Department under the ELKARTEK (KK-2021/00040) program. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | MDPI | es_ES |
dc.relation | info:eu-repo/grantAgreement/MICINN/PID2019-106099RB-C43 | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.subject | N-succinyl chitosan | es_ES |
dc.subject | aldehyde hyaluronic acid | es_ES |
dc.subject | hydrogels | es_ES |
dc.subject | dynamic bonds | es_ES |
dc.subject | self-healing | es_ES |
dc.title | Dynamic and Self-Healable Chitosan/Hyaluronic Acid-Based In Situ-Forming Hydrogels | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.date.updated | 2022-08-25T11:18:40Z | |
dc.rights.holder | © 2022 by the authors.Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/). | es_ES |
dc.relation.publisherversion | https://www.mdpi.com/2310-2861/8/8/477 | es_ES |
dc.identifier.doi | 10.3390/gels8080477 | |
dc.departamentoes | Química física | |
dc.departamentoeu | Kimika fisikoa |
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Excepto si se señala otra cosa, la licencia del ítem se describe como © 2022 by the authors.Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).