A Set of Reliable Samples for the Study of Biomarkers for the Early Diagnosis of Parkinson's Disease
dc.contributor.author | Konjevod, Marcela | |
dc.contributor.author | Saiz, Jorge | |
dc.contributor.author | Barbas, Coral | |
dc.contributor.author | Bergareche, Alberto | |
dc.contributor.author | Ardanaz, Eva | |
dc.contributor.author | Huerta, Jose María | |
dc.contributor.author | Vinagre Aragón, Ana | |
dc.contributor.author | Erro, María Elena | |
dc.contributor.author | Chirlaque, María Dolores | |
dc.contributor.author | Abilleira Cillero, Eunate | |
dc.contributor.author | Ibarluzea Maurolagoitia, Jesús María | |
dc.contributor.author | Amiano, Pilar | |
dc.date.accessioned | 2022-09-14T17:33:47Z | |
dc.date.available | 2022-09-14T17:33:47Z | |
dc.date.issued | 2022-05 | |
dc.identifier.citation | Frontiers in Neurology 13 : (2022) // Article ID 844841 | es_ES |
dc.identifier.issn | 1664-2295 | |
dc.identifier.uri | http://hdl.handle.net/10810/57732 | |
dc.description.abstract | BackgroundParkinson's disease (PD) is a progressive neurodegenerative disorder, diagnosed according to the clinical criteria that occur in already advanced stages of PD. The definition of biomarkers for the early diagnosis of PD represents a challenge that might improve treatment and avoid complications in this disease. Therefore, we propose a set of reliable samples for the identification of altered metabolites to find potential prognostic biomarkers for early PD. MethodsThis case-control study included plasma samples of 12 patients with PD and 21 control subjects, from the Spanish European Prospective Investigation into Cancer and Nutrition (EPIC)-Navarra cohort, part of the EPIC-Spain study. All the case samples were provided by healthy volunteers who were followed-up for 15.9 (+/- 4.1) years and developed PD disease later on, after the sample collection. Liquid chromatography coupled to tandem mass spectrometry was used for the analysis of samples. ResultsOut of 40 that were selected and studied due to their involvement in established cases of PD, seven significantly different metabolites between PD cases and healthy control subjects were obtained in this study (benzoic acid, palmitic acid, oleic acid, stearic acid, myo-inositol, sorbitol, and quinolinic acid). These metabolites are related to mitochondrial dysfunction, the oxidative stress, and the mechanisms of energy production. ConclusionWe propose the samples from the EPIC study as reliable and invaluable samples for the search of early biomarkers of PD. Likewise, this study might also be a starting point in the establishment of a well-founded panel of metabolites that can be used for the early detection of this disease. | es_ES |
dc.description.sponsorship | he EPIC study received financial support from the International Agency for Research on Cancer (AEP/93/06), the European Commission (SO-97-200302-05F02 and SP23-CT-2005-006438), the Health Research Fund (FIS) of the Spanish Ministry of Health, the Red Temática de Investigación Cooperativa de Centros de Cáncer (RTICCC C03/10 and RD06/0020), the Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), the participating Regional Governments of Andalusia, Basque Country, Murcia and Navarra, and the Catalan Institute of Oncology (ICO). This study was furthermore supported by the Ministry of Health of the Basque Government, Exp 201611098 | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Frontiers Media | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.subject | Parkinson's disease | es_ES |
dc.subject | biomarkers | es_ES |
dc.subject | metabolomics | es_ES |
dc.subject | fatty acids | es_ES |
dc.subject | EPIC-Navarra | es_ES |
dc.title | A Set of Reliable Samples for the Study of Biomarkers for the Early Diagnosis of Parkinson's Disease | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | © 2022 Konjevod, Sáiz, Barbas, Bergareche, Ardanaz, Huerta, Vinagre- Aragón, Erro, Chirlaque, Abilleira, Ibarluzea and Amiano. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. | es_ES |
dc.rights.holder | Atribución 3.0 España | * |
dc.relation.publisherversion | https://www.frontiersin.org/articles/10.3389/fneur.2022.844841/full | es_ES |
dc.identifier.doi | 10.3389/fneur.2022.844841 |
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