dc.contributor.author | Del Corte Solaguren-Beascoa, Xabier | |
dc.contributor.author | Maestro Burzaco, Aitor | |
dc.contributor.author | López Francés, Adrián | |
dc.contributor.author | Palacios Gambra, Francisco Javier | |
dc.contributor.author | Vicario Hernando, Javier | |
dc.date.accessioned | 2022-11-25T16:50:54Z | |
dc.date.available | 2022-11-25T16:50:54Z | |
dc.date.issued | 2022-11-18 | |
dc.identifier.citation | Molecules 27(22) : (2022) // Article ID 8024 | es_ES |
dc.identifier.issn | 1420-3049 | |
dc.identifier.uri | http://hdl.handle.net/10810/58557 | |
dc.description.abstract | An efficient general method for the synthesis of a wide family of α-aminophosphonate analogs of aspartic acid bearing tetrasubstituted carbons is reported through an aza-Reformatsky reaction of α-iminophosphonates, generated from α-aminophosphonates, in an umpolung process. In addition, the α-aminophosphonate substrates showed in vitro cytotoxicity, inhibiting the growth of carcinoma human tumor cell lines A549 (carcinomic human alveolar basal epithelial cell) and SKOV3 (human ovarian carcinoma). In view of the possibilities in the diversity of the substituents that offer the synthetic methodology, an extensive profile structure–activity is presented, measuring IC50 values up to 0.34 µM in the A549 and 9.8 µM in SKOV3 cell lines. | es_ES |
dc.description.sponsorship | Financial support by Ministerio de Economía, Industria y Competividad (PID2021-122558OB-I00) and Gobierno Vasco (GV-IT1701-22) is gratefully acknowledged. X.d.C. and A.L.-F. thank the Basque Country Government for a predoctoral grant. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | MDPI | es_ES |
dc.relation | info:eu-repo/grantAgreement/MICINN/PID2021-122558OB-I00 | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | Reformatsky reaction | es_ES |
dc.subject | tetrasubstituted α-aminophosphonates | es_ES |
dc.subject | aspartic acid | es_ES |
dc.subject | antiproliferative effect | es_ES |
dc.title | Synthesis of Tetrasubstituted Phosphorus Analogs of Aspartic Acid as Antiproliferative Agents | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.date.updated | 2022-11-24T14:43:34Z | |
dc.rights.holder | © 2022 by the authors.Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/ 4.0/). | es_ES |
dc.relation.publisherversion | https://www.mdpi.com/1420-3049/27/22/8024 | es_ES |
dc.identifier.doi | 10.3390/molecules27228024 | |