Discovery of 42 genome-wide significant loci associated with dyslexia

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Ikusi/Ireki
Data
2022
Egilea
Doust, Catherine
Fontanillas, Pierre
Eising, Else
Gordon, Scott D.
Wang, Zhengjun
Alagöz, Gökberk
Molz, Barbara
Research Team, 23andMe
Quantitative Trait Working Group of the GenLang Consortium* (Manuel Carreiras)
St Pourcain, Beate
Francks, Clyde
Marioni, Riccardo E.
Zhao, Jingjing
Paracchini, Silvia
Talcott, Joel B.
Monaco, Anthony P.
Stein, John F.
Gruen, Jeffrey R.
Olson, Richard K.
Willcutt, Erik G.
DeFries, John C.
Pennington, Bruce F.
Smith, Shelley D.
Wright, Margaret J.
Martin, Nicholas G.
Auton, Adam
Bates, Timothy C.
Fisher, Simon E.
Luciano, Michelle
Metadata
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Doust, C., Fontanillas, P., Eising, E. et al. Discovery of 42 genome-wide significant loci associated with dyslexia. Nat Genet 54, 1621–1629 (2022). https://doi.org/10.1038/s41588-022-01192-y
nature genetics
URI
http://hdl.handle.net/10810/62923
Laburpena
Reading and writing are crucial life skills but roughly one in ten children are affected by dyslexia, which can persist into adulthood. Family studies of dyslexia suggest heritability up to 70%, yet few convincing genetic markers have been found. Here we performed a genome-wide association study of 51,800 adults self-reporting a dyslexia diagnosis and 1,087,070 controls and identified 42 independent genome-wide significant loci: 15 in genes linked to cognitive ability/educational attainment, and 27 new and potentially more specific to dyslexia. We validated 23 loci (13 new) in independent cohorts of Chinese and European ancestry. Genetic etiology of dyslexia was similar between sexes, and genetic covariance with many traits was found, including ambidexterity, but not neuroanatomical measures of language-related circuitry. Dyslexia polygenic scores explained up to 6% of variance in reading traits, and might in future contribute to earlier identification and remediation of dyslexia.
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