Rhabdomyosarcoma: Current Therapy, Challenges, and Future Approaches to Treatment Strategies
dc.contributor.author | Zarrabi, Ali | |
dc.contributor.author | Perrin, David | |
dc.contributor.author | Kavoosi, Mahboubeh | |
dc.contributor.author | Sommer, Micah | |
dc.contributor.author | Sezen, Serap | |
dc.contributor.author | Mehrbod, Parvaneh | |
dc.contributor.author | Bhushan, Bhavya | |
dc.contributor.author | Machaj, Filip | |
dc.contributor.author | Rosik, Jakub | |
dc.contributor.author | Kawalec, Philip | |
dc.contributor.author | Afifi, Saba | |
dc.contributor.author | Bolandi, Seyed Mohammadreza | |
dc.contributor.author | Koleini, Peiman | |
dc.contributor.author | Taheri, Mohsen | |
dc.contributor.author | Madrakian, Tayyebeh | |
dc.contributor.author | Łos, Marek J. | |
dc.contributor.author | Lindsey, Benjamin | |
dc.contributor.author | Cakir, Nilufer | |
dc.contributor.author | Zarepour, Atefeh | |
dc.contributor.author | Hushmandi, Kiavash | |
dc.contributor.author | Fallah, Ali | |
dc.contributor.author | Koc, Bahattin | |
dc.contributor.author | Khosravi, Arezoo | |
dc.contributor.author | Ahmadi, Mazaher | |
dc.contributor.author | Logue, Susan | |
dc.contributor.author | Orive Arroyo, Gorka | |
dc.contributor.author | Pecic, Stevan | |
dc.contributor.author | Gordon, Joseph W. | |
dc.contributor.author | Ghavami, Saeid | |
dc.date.accessioned | 2023-11-27T17:21:58Z | |
dc.date.available | 2023-11-27T17:21:58Z | |
dc.date.issued | 2023-11-02 | |
dc.identifier.citation | Cancers 15(21) : (2023) // Article ID 5269 | es_ES |
dc.identifier.issn | 2072-6694 | |
dc.identifier.uri | http://hdl.handle.net/10810/63162 | |
dc.description.abstract | Rhabdomyosarcoma is a rare cancer arising in skeletal muscle that typically impacts children and young adults. It is a worldwide challenge in child health as treatment outcomes for metastatic and recurrent disease still pose a major concern for both basic and clinical scientists. The treatment strategies for rhabdomyosarcoma include multi-agent chemotherapies after surgical resection with or without ionization radiotherapy. In this comprehensive review, we first provide a detailed clinical understanding of rhabdomyosarcoma including its classification and subtypes, diagnosis, and treatment strategies. Later, we focus on chemotherapy strategies for this childhood sarcoma and discuss the impact of three mechanisms that are involved in the chemotherapy response including apoptosis, macro-autophagy, and the unfolded protein response. Finally, we discuss in vivo mouse and zebrafish models and in vitro three-dimensional bioengineering models of rhabdomyosarcoma to screen future therapeutic approaches and promote muscle regeneration. | es_ES |
dc.description.sponsorship | S.G. was supported by the URGP (56977) and CHRIM (OG2023-24-05) operating grant. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | MDPI | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.subject | alveolar rhabdomyosarcoma | es_ES |
dc.subject | apoptosis | es_ES |
dc.subject | autophagy | es_ES |
dc.subject | unfolded protein response | es_ES |
dc.subject | bioengineering | es_ES |
dc.subject | tumor stiffness | es_ES |
dc.subject | autophagy | es_ES |
dc.title | Rhabdomyosarcoma: Current Therapy, Challenges, and Future Approaches to Treatment Strategies | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.date.updated | 2023-11-10T14:58:12Z | |
dc.rights.holder | © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). | es_ES |
dc.relation.publisherversion | https://www.mdpi.com/2072-6694/15/21/5269 | es_ES |
dc.identifier.doi | 10.3390/cancers15215269 | |
dc.departamentoes | Farmacia y ciencias de los alimentos | |
dc.departamentoeu | Farmazia eta elikagaien zientziak |
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Except where otherwise noted, this item's license is described as © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).