Catalytic enantioselective domino Michael/transannular aldol reaction under bifunctional catalysis
Fecha
2020-09-28Autor
Mato Santamaría, Raquel
Reyes Martín, Efraim
Metadatos
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Chemical Communications 56 : 13149-13152(2020)
Resumen
The enantioselective Michael reaction catalyzed by a bifunctional tertiary amine/squaramide has been used to trigger a Michael/transannular aldol cascade process that leads to densely substituted bicyclo[5.4.0]undecanes and in which three contiguous stereogenic centres, one of them a tertiary alcohol moiety, have been formed in a fully stereocontrolled fashion.