dc.contributor.author | Palao, Eduardo | |
dc.contributor.author | Sola Llano, Rebeca | |
dc.contributor.author | Tabero, Andrea | |
dc.contributor.author | Manzano Moro, Hegoi | |
dc.contributor.author | Agarrabeitia, Antonia R. | |
dc.contributor.author | Villanueva, Angeles | |
dc.contributor.author | López Arbeloa, Iñigo María | |
dc.contributor.author | Martínez Martínez, Virginia | |
dc.contributor.author | Ortiz, María J. | |
dc.date.accessioned | 2024-02-08T09:55:02Z | |
dc.date.available | 2024-02-08T09:55:02Z | |
dc.date.issued | 2017-05-19 | |
dc.identifier.citation | Chemistry – A European Journal 23(42) : 9971-10229 (2017) | |
dc.identifier.issn | 0947-6539 | |
dc.identifier.issn | 1521-3765 | |
dc.identifier.uri | http://hdl.handle.net/10810/65165 | |
dc.description.abstract | Biscyclometalated Ir(III) complexes involving BODIPYbased ancillary ligands, where the BODIPY unit is grafted to different chelating cores (acetylacetonate for Ir-1 and Ir-2, and bipyridine for Ir-3) by the BODIPY meso position, have been synthesized and characterized. Complexes having the BODIPY moiety directly grafted to acetylacetonate (Ir-1 and Ir-2) exhibit higher absorption coefficient (ca. ε = 4.46 104 M-1 cm-1 and 3.38 104 M-1cm-1 at 517 nm and 594 nm, respectively), higher moderate-fluorescence emission (ca. fl = 0.08 and 0.22 at 528 nm and 652 nm, respectively) and, especially, more efficient singlet oxygen generation upon visible-light irradiation (ca. = 0.86 and 0.59, respectively) than that exhibited by Ir-3 (ca. = 0.51, but only under UV light). Phosphorescence emission, nanosecond time-resolved transient absorption and DFT calculations suggest that BODIPY-localized long-lived 3IL states are populated for Ir-1 and Ir-2. In-vitro photodynamic therapy (PDT) activity studied for Ir-1 and Ir-2 in HeLa cells shows that such complexes are efficiently internalized into the cells, exhibiting low dark- and high photo-cytoxicity, even at significant low complex concentration, making them potentially suitable as theranostic agents. | es_ES |
dc.description.sponsorship | Financial support from MINECO (MAT2014-51937-C-2-P and 3-P and MAT2015-68837-REDT), MICINN (CTQ2013-48767-C3-3-R), Comunidad de Madrid (S2013/MIT-2850) of Spain and Gobierno Vasco (IT912-16) is gratefully acknowledged. V. M-M.
thanks MINECO for a postdoctoral contract (RYC-2011-09505). R.S-L thanks UPV-EHU for a postdoctoral fellowship, and A.T. thanks UAM for a predoctoral contract. The authors thank for technical and human support provided by SGIker of UPV/EHU and European funding (ERDF and ESF). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Wiley-VCH GmbH, Weinheim | |
dc.relation | info:eu-repo/grantAgreement/MICINN/TQ2013-48767-C3-3-R | |
dc.relation | info:eu-repo/grantAgreement/MINECO/MAT2014-51937-C-2-P | |
dc.relation | info:eu-repo/grantAgreement/MINECO/MAT2014-51937-C-3-P | |
dc.relation | info:eu-repo/grantAgreement/MINECO/MAT2015-68837-REDT | |
dc.relation | info:eu-repo/grantAgreement/MINECO/RYC-2011-09505 | |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | Iridium(III) complex | es_ES |
dc.subject | BODIPYs | es_ES |
dc.subject | singlet oxygen | es_ES |
dc.subject | fluorescent-photosensitizers | es_ES |
dc.subject | photodynamic therapy | es_ES |
dc.subject | HeLa cells | es_ES |
dc.title | AcetylacetonateBODIPY−biscyclometalated Iridium(III) complexes: effective strategy towards smarte fluorescentphotosensitizer agents | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim | * |
dc.relation.publisherversion | https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/chem.201701347 | |
dc.identifier.doi | /10.1002/chem.201701347 | |
dc.departamentoes | Química física | es_ES |
dc.departamentoeu | Kimika fisikoa | es_ES |