dc.contributor.author | Vergara Luis, Irantzu | |
dc.contributor.author | Jin, M. | |
dc.contributor.author | Báez Millán, J. C. | |
dc.contributor.author | González Gaya, Belén | |
dc.contributor.author | Ijurco, I. | |
dc.contributor.author | Lacuesta Calvo, Maria Teresa | |
dc.contributor.author | Olivares Zabalandicoechea, Maitane | |
dc.contributor.author | Prieto Sobrino, Ailette | |
dc.date.accessioned | 2024-04-23T17:23:03Z | |
dc.date.available | 2024-04-23T17:23:03Z | |
dc.date.issued | 2024-06 | |
dc.identifier.citation | Food Chemistry 444 : (2024) // Article ID 138643 | es_ES |
dc.identifier.issn | 0308-8146 | |
dc.identifier.issn | 1873-7072 | |
dc.identifier.uri | http://hdl.handle.net/10810/66888 | |
dc.description.abstract | This work provided an accurate analytical method to perform a multitarget analysis of a variety of antimicrobials (AMs) including sulfonamides, tetracyclines, macrolides, fluoroquinolones and quinolones, one imidazole and one nitroimidazole, one triazole, one diaminopyridine and one derivative of Penicillium stoloniferum in vegetables. The analysis is performed using liquid-chromatography coupled to a low-resolution triple quadrupole mass spectrometer (UHPLC-MS/MS) to detect the target analytesor coupled to a high-resolution q-Orbitrap (HRMS) to monitor the formed transformation products (TPs). Both instruments were compared in terms of limits of quantification and matrix effect at the detection. The method was applied to determine the presence of AMs in organic and non-organic vegetables, where sulfadiazine and mycophenolic acid were detected. On the other hand, the transference of four AMs (trimethoprim, sulfamethazine, enrofloxacin, and chlortetracycline) from soils to lettuces was evaluated through controlled uptake experiments. The choice of AMs was based on the classification into different families, and on the fact that those AM families are the most frequently detected in the environment. In this case, each of the AMs with which the soils were contaminated were found in the exposed lettuces. Moreover, in both studies, specific TPs of the AMs were identified, posing the necessity of assessing their effects in relation to food and human safety. | es_ES |
dc.description.sponsorship | Authors acknowledge financial support from the Elkartek project entittled “Emergencia y diseminación de resistencia a los antibióticos: vínculos entre salud humana, ganadería, alimentación y medioambiente (Elkartek 20/88)”, the projects “Evaluación del riesgo de aparición y diseminación de resistencias a antibióticos en productos vegetales frescos y suelos de cultivo de la comunidad autónoma del País Vasco (PA21/05 and PA22/03)” inside the “Research projects targeted to agriculture 2020 program” of the Basque Government (Basque Country, Spain). Authors also thanks the financial support of the University of the Basque Country (UPV/EHU) from the collaborative project COLAB 20/14 “Assessment and preliminary diagnosis of dissemination of antibiotic resistance genes through the food production chain in the Basque Country”; and the Basque Government through the financial support as consolidated group of the Basque Research System (IT1446-22 and IT1682-22). I. Vergara-Luis is grateful to the University of the Basque Country (UPV/EHU) for her pre-doctoral fellowship. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Elsevier | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ | * |
dc.subject | antimicrobials | es_ES |
dc.subject | vegetables | es_ES |
dc.subject | UHPLC-MS/MS | es_ES |
dc.subject | q-Orbitrap | es_ES |
dc.subject | transformation products | es_ES |
dc.title | Multitarget and suspect-screening of antimicrobials in vegetables samples: Uptake experiments and identification of transformation products | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | © 2024 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-
nc-nd/4.0/) | es_ES |
dc.rights.holder | Atribución-NoComercial-SinDerivadas 3.0 España | * |
dc.relation.publisherversion | https://www.sciencedirect.com/science/article/pii/S0308814624002917 | es_ES |
dc.identifier.doi | 10.1016/j.foodchem.2024.138643 | |
dc.departamentoes | Biología vegetal y ecología | es_ES |
dc.departamentoes | Química analítica | es_ES |
dc.departamentoeu | Kimika analitikoa | es_ES |
dc.departamentoeu | Landaren biologia eta ekologia | es_ES |