Impact of polymorphisms in apoptosis-related genes on the outcome of childhood acute lymphoblastic leukaemia

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Fecha
2018-05-29
Autor
Cabezas, María
Camos, Mireia
Rives, Susana
García-Orad Carles, África ORCID
López López, Elixabet ORCID
Dapena, Josep L.
Caballín, María R.
Armengol, Gemma
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  Estadisticas en RECOLECTA
(LA Referencia)

British Journal of Haematology 185(1) :159-162 (2019)
URI
http://hdl.handle.net/10810/66966
Resumen
Despite intensification of therapy, 20% of children with acute lymphoblastic leukaemia (ALL) relapse (Ceppi et al, 2015). The different response to chemotherapy may be partially explained by inherited genetic variants, e.g. single nucleotide polymorphisms (SNPs) and copy number variants (CNVs). However, clinically useful genetic predictors of ALL treatment response are yet to be identified.
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