Genetic and environmental influences on adult human height across birth cohorts from 1886 to 1994
Ikusi/ Ireki
Data
2016-12-14Egilea
Jelenkovic Moreno, Aline
Hur, Yoon-M.
Sund, Reijo
Yokoyama, Yoshie
Siribaddana, Sisira H.
Hotopf, Matthew
Sumathipala, Athula
Rijsdijk, Fruhling
Tan, Qihua
Zhang, Dongfeng
Pang, Zengchang
Aaltonen, Sari
Heikkila, Kauko
Öncel, Sevgi Y.
Aliev, Fazil
Rebato, Esther
Tarnoki, Adam D.
Tarnoki, David L.
Christensen, Kaare
Skytthe, Axel
O Kyvik, Kirsten
Silberg, Judy L.
Eaves, Lindon J.
Maes, Hermine H.
Cutler, Tessa L.
Hopper, John L.
Ordoñana Martín, Juan Ramón
Sánchez Romera, Juan Francisco
Colodro Conde, Lucía
Cozen, Wendy
Hwang, Amie E.
Mack, Thomas M.
Sung, Joohon
Song, Yun-Mi
Yang, Sarah
Lee, Kayoung
Franz, Carol E.
Kremen, William S.
Lyons, Michael J.
Busjahn, Andreas
Nelson, Tracy L.
Whitfield, Keith E.
Kandler, Christian
Jang, Kerry L
Gatz, Margaret
Butler, David A.
Stazi, Maria A.
Fagnani, Corrado
D’Ippolito, Cristina
Duncan, Glen E.
Buchwald, Dedra
Derom, Catherine A.
Vlietinck, Robert F.
Loos, Ruth J.F.
Martin, Nicholas G.
Medland, Sarah E.
Montgomery, Grant W.
Jeong, Hoe-Uk
Swan, Gary E.
Krasnow, Ruth
Magnusson, Patrik K.E.
Pedersen, Nancy L.
Dahl-Aslan, Anna K.
McAdams, Tom A.
Eley, Thalia C.
Gregory, Alice M.
Tynelius, Per
Baker, Laura A.
Tuvblad, Catherine
Bayasgalan, Gombojav
Narandalai, Danshiitsoodol
Lichtenstein, Paul
Spector, Timothy D.
Mangino, Massimo
Lachance, Genevieve
Bartels, Meike
Van Beijsterveldt, Toos C.E.M.
Willemsen, Gonneke
Burt, S. Alexandra
Klump, Kelly L.
Harris, Jennifer R.
Brandt, Ingunn
Nilsen, Thomas Sevenius
Krueger, Robert F.
McGue, Matt
Pahlen, Shandell
Corley, Robin P.
Hjelmborg, Jacob v. B.
Goldberg, Jack H.
Iwatani, Yoshinori
Watanabe, Mikio
Honda, Chika
Inui, Fujio
Rasmussen, Finn
Huibregtse, Brooke M.
Boomsma, Dorret I.
Sørensen, Thorkild I. A.
Kaprio, Jaakko
Silventoinen, Karri
eLife 5 : (2016) // Art. ID e20320
Laburpena
Human height variation is determined by genetic and environmental factors, but it
remains unclear whether their influences differ across birth-year cohorts. We conducted an
individual-based pooled analysis of 40 twin cohorts including 143,390 complete twin pairs born
1886–1994. Although genetic variance showed a generally increasing trend across the birth-year
cohorts, heritability estimates (0.69-0.84 in men and 0.53-0.78 in women) did not present any clear
pattern of secular changes. Comparing geographic-cultural regions (Europe, North America and
Australia, and East Asia), total height variance was greatest in North America and Australia and
lowest in East Asia, but no clear pattern in the heritability estimates across the birth-year cohorts
emerged. Our findings do not support the hypothesis that heritability of height is lower in
populations with low living standards than in affluent populations, nor that heritability of height will
increase within a population as living standards improve.