dc.contributor.author | Marcos Arias, Cristina | |
dc.contributor.author | Eraso Barrio, María Elena | |
dc.contributor.author | Madariaga Torres, Lucila | |
dc.contributor.author | Quindós Andrés, Guillermo | |
dc.date.accessioned | 2012-03-30T18:28:36Z | |
dc.date.available | 2012-03-30T18:28:36Z | |
dc.date.issued | 2011-11-26 | |
dc.identifier.citation | BMC Complementary and Alternative Medicine 11(119) : (2011) | es |
dc.identifier.issn | 1472-6882 | |
dc.identifier.uri | http://hdl.handle.net/10810/7295 | |
dc.description.abstract | Background: Candida-associated denture stomatitis is a frequent infectious disease. Treatment of this oral condition is difficult because failures and recurrences are common. The aim of this study was to test the in vitro antifungal activity of pure constituents of essentials oils. --
Methods: Eight terpenic derivatives (carvacrol, farnesol, geraniol, linalool, menthol, menthone, terpinen-4-ol, and aterpineol), a phenylpropanoid (eugenol), a phenethyl alcohol (tyrosol) and fluconazole were evaluated against 38 Candida isolated from denture-wearers and 10 collection Candida strains by the CLSI M27-A3 broth microdilution method. -- Results: Almost all the tested compounds showed antifungal activity with MIC ranges of 0.03-0.25% for eugenol and linalool, 0.03-0.12% for geraniol, 0.06-0.5% for menthol, a-terpineol and terpinen-4-ol, 0.03-0.5% for carvacrol, and 0.06-4% for menthone. These compounds, with the exception of farnesol, menthone and tyrosol, showed important in vitro activities against the fluconazole-resistant and susceptible-dose dependent Candida isolates. -- Conclusions: Carvacrol, eugenol, geraniol, linalool and terpinen-4-ol were very active in vitro against oral Candida isolates. Their fungistatic and fungicidal activities might convert them into promising alternatives for the topic treatment of oral candidiasis and denture stomatitis. | es |
dc.description.sponsorship | Funding: this work has been funded in part by projects GIC07 123-IT-222-07 (Departamento de Educacion, Universidades e Investigacion, Gobierno Vasco), S-PR09UN01 and S-PR10UN03 (Saiotek 2009 and 2010, Departamento de Industria, Comercio y Turismo, Gobierno Vasco). | es |
dc.language.iso | eng | es |
dc.publisher | BioMed Central | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.subject | tea-tree oil | es |
dc.subject | albicans biofilms | es |
dc.subject | major components | es |
dc.subject | stomatitis | es |
dc.subject | etiology | es |
dc.subject | eugenol | es |
dc.subject | inhibition | es |
dc.subject | management | es |
dc.subject | cavity | es |
dc.title | In vitro activities of natural products against oral Candida isolates from denture wearers | es |
dc.type | info:eu-repo/semantics/article | es |
dc.rights.holder | © 2011 Marcos-Arias et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | es |
dc.relation.publisherversion | http://www.biomedcentral.com/1472-6882/11/119 | es |
dc.identifier.doi | 10.1186/1472-6882-11-119 | |
dc.departamentoes | Inmunología, microbiología y parasitología | es_ES |
dc.departamentoeu | Immunologia, mikrobiologia eta parasitologia | es_ES |
dc.subject.categoria | COMPLEMENTARY AND ALTERNATIVE MEDICINE | |