Toward Supramolecular Nanozymes for the Photocatalytic Activation of Pt(IV) Anticancer Prodrugs

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Date
2020-09-16
Author
Mazzei, Laura Filomena
Martínez, Álvaro
Trevisan, Lucia
Rosa Gastaldo, Daniele
López Cortajarena, Aitziber ORCID
Mancin, Fabrizio
Salassa, Luca
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Chemical Communications 56(72) : 10461-10464 (2020)
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http://hdl.handle.net/10810/50338
Abstract
A supramolecular nanozyme for the photocatalytic conversion of a Pt(IV) anticancer complex to cisplatin is described herein. We employed 1.9 nm Au nanoparticles decorated with thiol ligands bearing a TACN (1,4,7-triazacyclononane) headgroup to encapsulate FMN (riboflavin-5'-phosphate). In the presence of an electron donor, flavin-loaded nanoparticles photocatalyzed the reductive activation of the prodrug cis,cis,trans-[Pt(NH3)(2)(Cl-2)(O2CCH2CH2COOH)(2)] to cisplatin, achieving turnover frequency values of 7.4 min(-1).
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Except where otherwise noted, this item's license is described as This article is licensed under a Creative Commons Attribution Non Commercial (CC BY-NC 3.0)