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Toward Supramolecular Nanozymes for the Photocatalytic Activation of Pt(IV) Anticancer Prodrugs

dc.contributor.authorMazzei, Laura Filomena
dc.contributor.authorMartínez, Álvaro
dc.contributor.authorTrevisan, Lucia
dc.contributor.authorRosa Gastaldo, Daniele
dc.contributor.authorLópez Cortajarena, Aitziber ORCID
dc.contributor.authorMancin, Fabrizio
dc.contributor.authorSalassa, Luca
dc.date.accessioned2021-02-25T09:13:57Z
dc.date.available2021-02-25T09:13:57Z
dc.date.issued2020-09-16
dc.identifier.citationChemical Communications 56(72) : 10461-10464 (2020)es_ES
dc.identifier.issn1359-7345
dc.identifier.issn1364-548X
dc.identifier.urihttp://hdl.handle.net/10810/50338
dc.description.abstractA supramolecular nanozyme for the photocatalytic conversion of a Pt(IV) anticancer complex to cisplatin is described herein. We employed 1.9 nm Au nanoparticles decorated with thiol ligands bearing a TACN (1,4,7-triazacyclononane) headgroup to encapsulate FMN (riboflavin-5'-phosphate). In the presence of an electron donor, flavin-loaded nanoparticles photocatalyzed the reductive activation of the prodrug cis,cis,trans-[Pt(NH3)(2)(Cl-2)(O2CCH2CH2COOH)(2)] to cisplatin, achieving turnover frequency values of 7.4 min(-1).es_ES
dc.description.sponsorshipWe acknowledge financial support from the Spanish State Research Agency for the grants CTQ2016-80844-R, BIO201677367-R, PID2019-111649RB-I00 and PCI2018-092984. This work was performed under the Severo Ochoa Centres of Excellence and Maria de Maeztu Units of Excellence Program from the Spanish State Research Agency -Grant No. CEX2018-000867-S (DIPC) and MDM-2017-0720 (CIC biomaGUNE). We also thank Fondazione Cariparo (Ricerca Scientifica di Eccellenza Grant "SELECT''). A. M. has received funding from the European Union's Horizon 2020 Research and Innovation Programme under Marie SklodowskaCurie Actions grant no. 793702. We thank the Spanish MultiMetDrugs network (RED2018-102471-T) for fruitful discussion.es_ES
dc.language.isoenges_ES
dc.publisherRoyal Society Of Chemistryes_ES
dc.relationinfo:eu-repo/grantAgreement/MICINN/CTQ2016-80844-Res_ES
dc.relationinfo:eu-repo/grantAgreement/MICINN/BIO2016-77367-Res_ES
dc.relationinfo:eu-repo/grantAgreement/MICINN/PID2019-111649RB-I00es_ES
dc.relationinfo:eu-repo/grantAgreement/MICIU/PCI2018-092984es_ES
dc.relationinfo:eu-repo/grantAgreement/MICIU/CEX2018-000867-Ses_ES
dc.relationinfo:eu-repo/grantAgreement/MICIU/MDM-2017-0720es_ES
dc.relationinfo:eu-repo/grantAgreement/EC/H2020/793702es_ES
dc.relationinfo:eu-repo/grantAgreement/MICIU/RED2018-102471-Tes_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc/3.0/es/*
dc.subjectcatalysises_ES
dc.subjectplatinumes_ES
dc.titleToward Supramolecular Nanozymes for the Photocatalytic Activation of Pt(IV) Anticancer Prodrugses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.holderThis article is licensed under a Creative Commons Attribution Non Commercial (CC BY-NC 3.0)es_ES
dc.rights.holderAtribución-NoComercial 3.0 España*
dc.relation.publisherversionhttps://pubs.rsc.org/en/content/articlelanding/2020/CC/D0CC03450A#!divAbstractes_ES
dc.identifier.doi10.1039/d0cc03450a
dc.contributor.funderEuropean Commission
dc.departamentoesCiencia y tecnología de polímeroses_ES
dc.departamentoeuPolimeroen zientzia eta teknologiaes_ES


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